一项队列研究表明,慢性肾脏疾病对性功能变化的影响取决于治疗

IF 0.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
J. Fryckstedt, M. Norrbäck, Charlotte Kaviani, B. Hylander
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引用次数: 0

摘要

慢性肾脏疾病(CKD)患者在很大程度上报告性功能障碍。本研究的目的是调查CKD分期和治疗方式是否与没有积极治疗、移植或透析后出现症状性CKD患者前后自我报告的性功能经历相关。参与者(N = 234)回答了一份关于性欲、主动性、性交、勃起(男性)/阴道润滑(女性)和性高潮频率的问卷,目前与症状性慢性肾病发病前进行了比较。临床资料取自医学图表。比较未接受积极治疗的患者(PreT)、肾移植患者(Tx)和接受透析治疗的患者(D)的组内性功能差异。在亚组分析中,根据治疗方式和CKD分期划分了5组患者。性功能的组间差异以平均综合评分和95% CI的差异进行分析,并使用具有稳健标准误差的普通最小二乘回归进行估计。在该研究的第一个分析中,与疾病发作前相比,所有CKD患者的性欲、主动性、性交、勃起(男性)/阴道润滑(女性)和性高潮的频率(Bonferroni p < 0.001)均有所下降,与治疗模式无关。在亚组分析中,当对性别和年龄进行调整时,透析患者的性功能平均分(- 2.65;95% CI:−4.19 ~−1.11;p = 0.001),与未经积极治疗的CKD 2-3患者(对照组)相比。随着时间的推移,性功能恶化的CKD患者的自我报告经历与治疗方式和CKD分期相关。无论采用何种治疗方式,保健人员都应了解患者的性功能随着时间的推移而恶化的经历。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chronic kidney disease report differently on change in sexual function dependent on treatment: a cohort study
Patients with Chronic Kidney Disease (CKD) report sexual dysfunction to a large extent. The objective of this study was to investigate if CKD-stage and mode of treatment correlate to self-reported experience in sexual function before and after onset of symptomatic CKD in patients without active treatment, after transplantation or on dialysis. Participants (N = 234) answered a questionnaire on frequency of sexual desire, initiative, intercourse, erection (men) /vaginal lubrication (women), and orgasm, currently and compared with before onset of symptomatic CKD. Clinical data were taken from medical charts. Within-group differences in sexual function were compared for patients without active treatment (PreT), patients with a renal transplant (Tx) and patients on dialysis treatment (D). In a subgroup analysis, five patient groups were created based on mode of treatment and CKD stage. Between-group differences in sexual function were analyzed as differences in mean composite scores and 95% CI and were estimated using ordinary least square regression with robust standard errors. In the first analysis of the study, all CKD patients reported a decrease in the frequency of sexual desire, initiative, intercourse, erection (men)/vaginal lubrication (women), and orgasm (Bonferroni p < 0.001) compared to before disease onset, irrespective of treatment mode. In the subgroup analysis, when adjusting for sex and age, dialysis patients reported a statistically significant decrease in their average score of sexual function (−2.65; 95% CI: −4.19 to −1.11; p = 0.001) compared to patients without active treatment CKD 2–3 (the reference group). The self-reported experience of CKD-patients of a deteriorating sexual function over time correlates to treatment modality and CKD stage. It is important for health-care personnel to be aware of the patients' experience of a deterioration in sexual function over time regardless of treatment modalities.
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来源期刊
AIMS Medical Science
AIMS Medical Science MEDICINE, RESEARCH & EXPERIMENTAL-
自引率
14.30%
发文量
20
审稿时长
12 weeks
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