Research progress on pathogenesis of suilysin of Streptococcus suis type 2

Functional virulence factors investigation is of importance for understanding the possible pathogenesis of zoonotic Streptococcus suis type 2 (SS2) infection SS2 infected pigs only transmitted to humans, and can cause symptoms such as septicemia, endocarditis, arthritis and meningitis. The exploration of virulence factors and their functions has been an important research direction of the pathogenic mechanism of Streptococcus suis . Suilysin, a traditional secretory effector, is always regarded as one of the typical virulence markers. Biological properties and virulent effects as well as the newly progress of suilysin factor on the pathogenic roles of bacterial adhesion and invasion, immune evasion and penetrating blood brain barrier are summarized. This review will provide a better guidance for promoting SS2 pathogenesis research and investigation of the possible function of hemolysin in other Streptococcus species. 摘要： 猪链球菌( Streptococcus suis )是一种重要的人畜共患病原菌,其中猪链球菌2型( Streptococcus suis type 2, SS2)致病性最强、发病率最髙,SS2患病猪只传染给人,可导致败血症、心内膜炎、关节炎及脑膜炎等症状。关于其毒力因子 的挖掘与功能探索一直是猪链球菌致病机理研究的重要方向。溶血素(Sly)作为猪链球菌2型分泌性毒力因子,一直 被视为是SS2的毒力标志因子之一,在细菌感染与致病过程中扮演重要作用。本文阐述了猪链球菌2型溶血素因子的 溶血特性与分子结构,并重点论述Sly因子在介导SS2的黏附与侵袭、细菌繁殖与免疫逃避、突破血脑屏障与诱导脑膜 炎等感染生物学过程中的作用。以期为推进猪链球菌基础研究及其他链球菌溶血素因子的机制探索提供参考。