MMP-9基因多态性和浓度对乌克兰人群冠状动脉疾病发展的影响

IF 1.8 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiology Research and Practice Pub Date : 2022-04-11 DOI:10.1155/2022/2067632

O. Pogorielova, V. Korniienko, Yaroslav D Chumachenko, O. Obukhova, I. Martsovenko, V. Harbuzova

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引用次数: 4

摘要

冠状动脉疾病(CAD)是欧洲主要的死亡原因之一。众所周知，动脉粥样硬化是冠心病发生的主要危险因素。MMP-9参与动脉粥样硬化的所有阶段，因此可能有助于CAD的出现。为探讨MMP-9对冠心病发展的影响，本研究纳入25例完整冠状动脉(CA)患者、40例急性冠状动脉综合征(ACS)患者和63例慢性冠状动脉综合征(CCS)患者。采用Real-time PCR对rs17567多态性位点进行基因分型，ELISA检测MMP-9血药浓度。ag -携带者发生心肌梗死的风险较低(Pa=0.023;ORa = 0.299, 95% CI = 0.106-0.848)。

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Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population

Coronary artery disease (CAD) is one of the leading causes of death in Europe. It is known that atherosclerosis is the primary risk factor of CAD development. MMP-9 is involved in all stages of atherosclerosis and thus may contribute to CAD emergence. To investigate the influence of MMP-9 on the (CAD) development 25 patients with intact coronary arteries (CA), 40 patients with acute coronary syndrome (ACS), and 63 patients with chronic coronary syndrome (CCS) were enrolled in the study. Real-time PCR was carried out for genotyping on the rs17567-polymorphic locus, and ELISA study was performed to measure the MMP-9 plasma concentration. It was found the lower risk of MI occurrence for AG-carriers (Pa=0.023; ORa = 0.299, 95% CI = 0.106–0.848) in Ukrainian population.

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来源期刊

Cardiology Research and Practice Medicine-Cardiology and Cardiovascular Medicine

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Cardiology Research and Practice is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies that focus on the diagnosis and treatment of cardiovascular disease. The journal welcomes submissions related to systemic hypertension, arrhythmia, congestive heart failure, valvular heart disease, vascular disease, congenital heart disease, and cardiomyopathy.