8-氧-2'-脱氧鸟苷-生物标志物，信号分子，潜在药物制剂

Vestnik Volgogradskogo Gosudarstvennogo Universiteta Seria 11 Estestvennye Nauki Pub Date : 2018-08-01 DOI:10.15688/JVOLSU11.2018.1.9

N. Marmiy, D. Esipov

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引用次数: 1

摘要

该研究致力于8-oxo-2'-脱氧鸟苷(8-oxo-dG)，它被用作DNA氧化损伤及其相关疾病的生物标志物。该研究基于作者提出的8-oxo-dG (DNA氧化的主要产物)作为激活细胞抵抗非特异性应激和DNA修复的信号分子的能力的假设。除了研究8-oxo-dG作用的分子机制外，作者还对其在生物水平上造成的影响进行了调查。

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8-Oxo-2'-Deoxyguanosine - Biomarker, Signal Molecule, Potential Pharmaceutical Agent

The study is devoted to 8-oxo-2'-deoxyguanosine (8-oxo-dG), which is used as a biomarker of oxidative damage to DNA and its associated diseases. The study is based on the hypothesis put forward by the authors about the ability of 8-oxo-dG, which is the main product of DNA oxidation, to act as a signal molecule that activates cell resistance to nonspecific stress and DNA repair. In addition to studying the molecular mechanisms of the action of 8-oxo-dG, the authors have carried out an investigation of the effects that they caused on the organism level.

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Vestnik Volgogradskogo Gosudarstvennogo Universiteta Seria 11 Estestvennye Nauki

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审稿时长

7 weeks