F. Sanal, E. Bakar, M. Inan, E. Uluçam, A. Cerkezkayabekir
{"title":"Mesna对肠缺血再灌注引起的远端脏器损伤具有抗氧化作用","authors":"F. Sanal, E. Bakar, M. Inan, E. Uluçam, A. Cerkezkayabekir","doi":"10.23902/trkjnat.1123792","DOIUrl":null,"url":null,"abstract":"An ischemia-reperfusion (I/R) injury of small intestine is a serious and common condition that is a result of the blockage of the superior mesenteric artery (SMA) because of significant clinical problems. This study evaluated the effect of Mesna on systemic injury induced by ischemia/reperfusion (IR) in small intestine and also in liver, kidney and lung as remote organs. Forty Wistar albino rats were randomly divided into four groups: control, ischemia, IR and Mesna. Ischemia period was executed by clamping superior mesenteric artery (SMA) for 2 h and then reperfusion was permitted by removing the clamp from SMA for 2 h. Activities of antioxidant enzymes levels were measured in all tissue samples. Microscopic examination was performed for light and electron microscope. Oxidative damage was determined in ischemia (p","PeriodicalId":23163,"journal":{"name":"Trakya University Journal of Natural Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5000,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"MESNA HAS ANTIOXIDANT POTENTIAL ON INTESTINE REMOTE ORGAN INJURY INDUCED BY INTESTINAL ISCHEMIA/ REPERFUSION\",\"authors\":\"F. Sanal, E. Bakar, M. Inan, E. Uluçam, A. Cerkezkayabekir\",\"doi\":\"10.23902/trkjnat.1123792\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"An ischemia-reperfusion (I/R) injury of small intestine is a serious and common condition that is a result of the blockage of the superior mesenteric artery (SMA) because of significant clinical problems. This study evaluated the effect of Mesna on systemic injury induced by ischemia/reperfusion (IR) in small intestine and also in liver, kidney and lung as remote organs. Forty Wistar albino rats were randomly divided into four groups: control, ischemia, IR and Mesna. Ischemia period was executed by clamping superior mesenteric artery (SMA) for 2 h and then reperfusion was permitted by removing the clamp from SMA for 2 h. Activities of antioxidant enzymes levels were measured in all tissue samples. Microscopic examination was performed for light and electron microscope. Oxidative damage was determined in ischemia (p\",\"PeriodicalId\":23163,\"journal\":{\"name\":\"Trakya University Journal of Natural Sciences\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2022-10-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trakya University Journal of Natural Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.23902/trkjnat.1123792\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trakya University Journal of Natural Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23902/trkjnat.1123792","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
MESNA HAS ANTIOXIDANT POTENTIAL ON INTESTINE REMOTE ORGAN INJURY INDUCED BY INTESTINAL ISCHEMIA/ REPERFUSION
An ischemia-reperfusion (I/R) injury of small intestine is a serious and common condition that is a result of the blockage of the superior mesenteric artery (SMA) because of significant clinical problems. This study evaluated the effect of Mesna on systemic injury induced by ischemia/reperfusion (IR) in small intestine and also in liver, kidney and lung as remote organs. Forty Wistar albino rats were randomly divided into four groups: control, ischemia, IR and Mesna. Ischemia period was executed by clamping superior mesenteric artery (SMA) for 2 h and then reperfusion was permitted by removing the clamp from SMA for 2 h. Activities of antioxidant enzymes levels were measured in all tissue samples. Microscopic examination was performed for light and electron microscope. Oxidative damage was determined in ischemia (p
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