血红蛋白变异对血糖指数的影响

Victor Tuanwii, Jonathan, Nyebuchi, Albert Lesere Nwibani, Friday Ogidigba, Felix Eedee Konne, Fyneface Chikadibia Amadi
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引用次数: 0

摘要

众所周知,血红蛋白基因型与糖尿病等一系列疾病有关。本研究的目的是评估血红蛋白变异对尼日利亚巴耶尔萨州受试者血糖指数(空腹血糖和糖化血红蛋白)的影响。共入组150例,AA组99例,AS组51例。每位受试者取血4ml,装于EDTA瓶中,分别用电泳法和自动CLOVER A1c分析仪检测Hb电泳和糖化血红蛋白(HbA1C)。取2ml装草酸氟瓶,分光光度法测定空腹血糖。结果显示,两组(AA组和AS组)的FBG和HbA1C平均水平无显著差异。本研究表明,AA和AS血基因型可能对FBG和HbA1C血糖参数没有任何影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Haemoglobin Variants on Glycemic Indices
Haemoglobin genotypes have been known to be linked with groups of diseases such as diabetes. The aim of this study is to assess the impact of haemoglobin variants on glycemic indices (fasting blood glucose and glycated haemoglobin) in subjects in Bayelsa State, Nigeria. A total of 150subjects were enrolled for the study with AA group = 99 subjects and AS group = 51 subjects. 4mls of blood was collected into EDTA bottle for each subject and was assayed for Hb electrophoresis and glycated haemoglobin (HbA1C) using electrophoretic method and automated CLOVER A1c Analyser respectively. 2mls was collected into fluoride oxalate bottle for spectrophotometric analysis of fasting blood glucose (FBG). Results revealed that there were no significant differences in the FBG and HbA1C  mean  levels of the two studied groups (AA and AS). This study has shown that AA and AS blood genotypes may not have any impact on FBG and HbA1C glycemic parameters.
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