标准化胡芦巴籽提取物糠甾醇皂苷和肌醇(Nutricyst-M)对PCOS患者胰岛素抵抗(IR)和卵巢体积的疗效评价

A. Jaipuriar, A. Malik, G. Lamgora
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摘要

多囊卵巢综合征(PCOS)目前影响了近6-10%的育龄妇女。胰岛素抵抗伴代偿性高胰岛素血症是PCOS女性的常见特征,越来越多的证据表明高胰岛素血症在PCOS的发病机制中起重要作用,为PCOS的新治疗指明了方向。该研究计划采用一种天然替代药物标准胡芦巴籽提取物作为糠甾醇皂苷和肌醇。胡芦巴籽提取物含有生物活性成分糠甾醇皂苷,从胡芦巴籽中提取的皂苷可改善胰岛素敏感性,进而调节循环雄激素水平。它可以改善多囊卵巢综合征女性胰岛素介导的葡萄糖处理[1,2]。它还降低了促黄体生成素elh /FSH(促卵泡激素)的比例,这是我在上一项研究中观察到的[2-4]。肌醇不仅通过降低多囊卵巢综合征女性和非多囊卵巢综合征女性的雄性激素来提高生育能力,而且还可以改善多囊卵巢综合征女性的排卵。此外,肌醇还能降低胰岛素抵抗,提高雌激素水平。肌醇降低睾酮、黄体生成素和胰岛素水平。本观察研究的目的是建立治疗IR和卵巢体积的有效性和安全性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy Evaluation of Standardized Fenugreek seeds extract as Furostanolic Saponins & Myo-Inositol (Nutricyst-M) in Management of Insulin Resistance (IR) & Ovary Volume in PCOS Subjects
Polycystic ovarian syndrome (PCOS) currently affects nearly 6-10% of women of reproductive age. A frequent feature of women with PCOS is insulin resistance accompanied by compensatory hyperinsulinemia, and increasing evidence suggests that hyperinsulinemia plays an important role in the pathogenesis of PCOS, pointing the way to new and novel therapy for PCOS. The study was planned with one natural alternative remedy Standardized Fenugreek seeds extract as FurostanolicSaponins and Myo-Inositol.Standardized Fenugreek seeds extract as Furostanolic saponins which contains bioactive components Saponins extracted from Fenugreek seeds improves insulin sensitivity and, in turn, may regulate circulating androgen levels. It improves insulin-mediated glucose disposal in women with PCOS [1,2]. It also decreased theLuteinizing HormoneLH/FSH (Follicle- Stimulating Hormone) ratio as observed in my last study [2-4]. Myo-inositol not only improves fertility by lowering male sex hormones in both, women with and without PCOS but it could also improve ovulation in women with PCOS. In addition, Myo-inositol also reduces insulin resistance and increases estrogen levels. Myo-inositol reduced testosterone, LH, and insulin levels. The present observation study is to establish efficacy and safety in management of IR and ovarian volume.
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