结直肠癌患者的社会人口统计学特征和HER2状态

Chattagram Maa-O-Shishu Hospital Medical College Journal Pub Date : 2022-05-19 DOI:10.3329/cmoshmcj.v21i1.59761

Shamima Khanam, Tirtha Khastagir, Rahat Anjum, Mitasree Barua, M. Khatun, M. Z. Rahman

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引用次数: 0

摘要

背景:结直肠癌(CRC)是世界范围内最常见的恶性肿瘤。孟加拉国的结直肠癌发病率为3.5%。关于HER-2/neu在结直肠癌中过表达的患病率，存在矛盾的数据，范围从0到83%。本研究的目的是评估Her-2/neu蛋白在结直肠癌中的表达。材料和方法:本描述性横断面研究于2017年1月1日至2017年12月31日在孟加拉国吉大港吉大港医学院病理科进行。本研究共纳入52例经组织病理学诊断为结直肠癌的病例作为样本量，采用免疫组化(IHC)方法在福尔马林固定、石蜡包埋的组织中评估HER2状态。阳性表达评分为0-3 +。对ihc进行结肠癌分级分析。结果:本组患者平均年龄47.62岁，年龄12 ~ 85岁，女性占53.8%。52例标本中，30例(57.7%)来自结肠，全部为腺癌，其余全部来自直肠(42.3%)1级63.5%，2级8例(15.4%)，3级11例(21.2%)。52例中HER2阳性8例(15.4%)，4例(50.0%)为ⅱ级肿瘤，4例(50.0%)为ⅱ级肿瘤。HER2过表达与高分化CRC的相关性显著高于低分化CRC (p=0.044)。结论:HER2/neu蛋白在结直肠癌中有表达，但HER2/neu蛋白在结肠癌细胞系中表达较少。上海医科大学医学院;月(1);2022年1月;页面52-56

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Socio Demographic Profile and HER2 Status in Patients with Colorectal Carcinoma

Background : Colorectal carcinoma (CRC) is the most frequently observed malignancy worldwide. The incidence of CRC is 3.5% in Bangladesh. Conflicting data exist about the prevalence of HER-2/neu over expression in colorectal cancer ranging from 0 to 83%. The aim of this study was to evaluate the expression of Her-2/neu protein in colorectal cancers. Materials and methods: This descriptive cross-sectional study was conducted in the Department of Pathology of Chittagong Medical College, Chittagong, Bangladesh from 1st January 2017 to 31st December 2017. A total of 52 cases with a histopathological diagnosis of colorectal cancers included in the study as sample size, HER2 status was evaluated by immunohistochemistry (IHC) in formalin fixed, paraffin embedded tissue.Positive expression was assigned a score from 0–3+.IHCs were analysed with grades of colon cancers. Results: The mean age in this study was 47.62years range from 12 to 85 years ,53.8% were female. Among 52 specimens 30 (57.7%) cases were from colon and all the cases were adenocarcinoma and rest of all (42.3%) were from rectum.33 (63.5%) cases were Grade-I, 8 (15.4%) were Grade-II, and 11 (21.2%) were Grade-III. Only 8 (15.4%) of 52 cases showed HER2 positive, 4 (50.0%) cases were from grade- Iand another 4 (50.0%) were grade- II tumours. HER2 overexpression were significantly associated with well differentiated CRC than poorly differentiated (p=0.044). Conclusion: HER2/neu protein expression was observed in colorectal cancer but HER-2/neu protein is less likely to be expressed in colon cancer cell lines among our patients. Chatt Maa Shi Hosp Med Coll J; Vol.21 (1); January 2022; Page 52-56

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Chattagram Maa-O-Shishu Hospital Medical College Journal

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