小胶质细胞对小鼠成年神经元突触的修剪依赖于磷脂酰丝氨酸

The Tokushima journal of experimental medicine Pub Date : 2022-03-17 DOI:10.1084/jem.20202304

Chihiro Kurematsu, Masato Sawada, M. Ohmuraya, Motoki Tanaka, Kazuya Kuboyama, Takashi Ogino, M. Matsumoto, Hisashi Oishi, H. Inada, Yuri Ishido, Yukina Sakakibara, Huy Bang Nguyen, T. Q. Thai, S. Kohsaka, N. Ohno, M. Yamada, Masato Asai, M. Sokabe, J. Nabekura, K. Asano, Masato Tanaka, K. Sawamoto

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引用次数: 20

摘要

成年神经元突触修剪的机制尚不清楚。在这项研究中，Kurematsu等人证明磷脂酰丝氨酸参与了嗅球和海马中成年出生神经元的小胶质脊椎修剪和功能成熟。

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Synaptic pruning of murine adult-born neurons by microglia depends on phosphatidylserine

Mechanisms for synaptic pruning of adult-born neurons remain unknown. In this study, Kurematsu et al. demonstrate that phosphatidylserine is involved in microglial spine pruning and functional maturation of adult-born neurons in the olfactory bulb and hippocampus.

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The Tokushima journal of experimental medicine

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