The Body Weight and Thickness in Chicken Embryo Incubated for 10 Days Induced by Turmeric Rhizome Simplisia

: The zygote develops into an embryo after going through the process of organogenesis. During organogenesis, there is also the process of angiogenesis, the formation of blood vessels. However, the process of angiogenesis can be hampered by several factors including the presence of foreign compounds that enter the parent body. One compound that is believed to have an angiogenesis inhibiting effect is curcumin from the turmeric rhizome simplisia. Inhibition of angiogenesis due to curcumin induction can have an impact on embryonic organogenesis in terms of embryonic body weigth and thicness so this study was conducted to determine the teratogenic effects of curcumin of turmeric rhizome simplisia on chicken embryos. This study used fifteen unincubated chicken eggs divided into three groups, the negative control group, the group injected with turmeric rhizome simplisia at a dose of 0.48 mg/gr and DMSO 2% as much as 0.25 mL, and the group injected with turmeric rhizome simplisia at a dose of 0.96 mg/gr and DMSO 2% as much as 0.25 mL. All groups were incubated for 10 days at 38 °C. The parameters measured were embryo body weight use digital scales and measurement of the body thicness with calipers. The results showed that the turmeric rhizome simplisia at dose of 0,48,mg/gr cause died in one of incubated chicken egg and at dose of 0.96 mg/gr cause two of five incubated chicken egg was died. The left eggs from group of dose 0.48 mg/gr and 0.98 mg/gr have decreased of body weight and thicness compared with negative control group. It was showed that turmeric rhizome simplicial in this doses have effect in decrease body weight and thickness of chicken embryos.