Effect of Saffron (Crocus sativus L) on Common NonCommunicable Disease: Review from Current Clinical Findings

Background: Due to the high prevalence of NCDs and treatment costs, many medical providers are looking for alternative medications, especially herbal medicine, and some herbal medicines can be used as an effective therapy for the treatment of NCDs. Many studies have shown the effective use of saffron to impede and treat different types of non-communicable diseases. Aim: This current review focuses on the medicinal uses of saffron and current findings relating to the effects of saffron on different types of non-communicable diseases. Methods: Cochrane library, Pub Med, and Google Scholar databases were searched from 2000 to 2020 before September to accumulate current findings with the limitation of the English language. Result: A total of 33 studies (8 human and 25 animalstudies) were identified through searching. Saffron and its active components improved lipid profile along with lowering the risk of cardiovascular disease, hypertension, diabetes, and obesity. Kidney function was also improved by reducing nitrogen urea, urinary citrate, uric acid, etc. Saffron can be also used for treating different types of cancer like prostate cancer, skin cancer, breast cancer, etc. Conclusion: Despite the beneficial effects of saffron on non-communicable diseases, more prospective clinical trials among humans and animals are needed for a better understanding of the effects and mechanisms of saffron and its compounds.