degu阴道平滑肌肉瘤1例报告

M. Škorič, P. Fictum, V. Jekl, K. Hauptman, Z. Knotek, M. Hermanová
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引用次数: 8

摘要

一只6岁的雌性宠物德古犬(德古章鱼),身体状况良好,因肛门生殖器区域存在一个大肿瘤而被转介到诊所。肿块直接从周围皮肤和肌肉中剥离。肿瘤的内侧部分与阴道壁相关,阴道壁也切除了2mm的边缘。阴道内表面未见明显变化。大体检查,肿块表面有光泽,呈粉红色;切面灰红色,局部可见灰白色病灶。组织病理学检查显示肿瘤由多形性梭形到卵形细胞组成,形成交错的束和由肿瘤细胞流分离的不同密度的纤维结缔组织。肿瘤组织内可见几个较小的凝固性坏死灶。肿瘤细胞表现出较高的有丝分裂指数,每10个高倍视场有丝分裂6 - 7次。通过免疫组化检查,肿瘤细胞的平滑肌肌动蛋白(SMA)和波形蛋白呈阳性,而细胞角蛋白无免疫反应性。根据肿瘤的形态学特征和免疫组化检查,诊断为阴道平滑肌肉瘤。据我们所知,这是首例阴道平滑肌肉瘤的报道。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vaginal leiomyosarcoma in a degu ( Octodon degus): a case report
A 6-year-old pet female degu ( Octodon degus), in good body condition, was referred to a clinic with the presence of a large tumour in the anogenital area. The mass was bluntly dissected from the surrounding skin and muscles. The medial part of the tumour was associated with the vaginal wall which was also excised with 2 mm margins. No visible changes on the inner vaginal surface were seen. On gross examination the surface of the mass was glossy and pink-coloured; the cut surface was grey to red with greyish-white foci in a part of the mass. Histopathological examination showed a tumour composed of pleomorphic spindle to ovoid cells forming interlacing bundles and variably dense fibrous connective tissue separated by streams of neoplastic cells. Sev - eral smaller foci of coagulation necrosis were present within the tumour tissue. The neoplastic cells exhibited a high mitotic index, which ranged from six to seven mitoses per 10 high power fields. By immunohistochemical examination the positivity of neoplastic cells was demonstrated with smooth muscle actin (SMA) and vimentin, while no immunoreactivity was acquired for cytokeratins. Based on morphological features of the tumour and immunohistochemical examination a diagnosis of vaginal leiomyosarcoma was made. To our knowledge, this is the first report of a vaginal leiomyosarcoma in a degu.
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