足球草根水提物对四氧嘧啶诱导的糖尿病大鼠的抗糖尿病活性

M. Yakubu, M. Akanji, M. O. Nafiu
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引用次数: 24

摘要

采用四氧嘧啶诱导的糖尿病大鼠,研究了足底草根水提物的抗糖尿病活性。将30只白化病大鼠(110.33±8.69 g)随机分为6组(A- f),其中A组(非糖尿病)给予蒸馏水0.5 ml,每日3次,连续10 d。B组、C组、D组、E组和F组均以四氧嘧啶(150 mg/kg b.w, i.p.)致糖尿病,同时分别给予格列本脲0.5 ml (2.5 mg/kg b.w, p.o.)、25、50和100 mg/kg b.w, p.o.。经四氧化处理48h后,大鼠血糖值在20.50 ~ 30.20 mmol/L范围内显著降低(P草根具有与参比药相似的抗高血糖活性)。足球草根提取物对糖尿病相关的代谢紊乱也有一定的控制作用。关键词:四氧嘧啶,铁精科,铁精,糖尿病,代谢性疾病,格列本脲
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anti-diabetic activity of aqueous extract of Cochlospermum planchonii root in alloxan-induced diabetic rats
Aqueous extract of Cochlospermum planchonii root was investigated for antidiabetic activity in alloxan-induced diabetic rats. Thirty albino rats (110.33 ± 8.69 g) were randomized into six groups (A-F) such that group A (non-diabetic) received orally 0.5 ml of distilled water, thrice daily for 10 days. Animals in groups B, C, D, E and F which were all made diabetic with alloxan (150 mg/kg b. w., i.p.) also received 0.5 ml of glibenclamide (2.5 mg/kg b. w., p.o.), 25, 50 and 100 mg/kg b. w., p.o. of the extract respectively. The blood glucose of the alloxanized rats after 48 hours which ranged from 20.50-30.20 mmol/L were significantly (P Cochlospermum planchonii root possesses anti-hyperglycemic activity similar to the reference drug. The extract of Cochlospermum planchonii root is also effective in controlling some of the disorders of metabolism associated with diabetes. Keywords: Alloxan, Cochlospermaceae, Cochlospermum planchonii, Diabetes, Metabolic disorders, Glibenclamide
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