{"title":"Pax基因在小鼠发育中的作用","authors":"Luc St-Onge , Fabienne Pituello , Peter Gruss","doi":"10.1016/S1044-5781(06)80054-X","DOIUrl":null,"url":null,"abstract":"<div><p>Members of the <em>Pax</em> gene family exhibit distinct temporal and spatial expression patterns during murine embryogenesis. Their unique expression in the central nervous system implies a role in the regionalization of the spinal cord and early brain. <em>Pax</em> proteins are localized in the cell nucleus and possess a DNA-binding activity. This makes them good candidates for transcriptional regulator of developmental processes. Mutations in three <em>Pax</em> genes have been associated with three mouse mutants and two human diseases indicating that their activity is necessary for proper development of the embryo</p></div>","PeriodicalId":101155,"journal":{"name":"Seminars in Developmental Biology","volume":"6 4","pages":"Pages 285-292"},"PeriodicalIF":0.0000,"publicationDate":"1995-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1044-5781(06)80054-X","citationCount":"10","resultStr":"{\"title\":\"The role of Pax genes during murine development\",\"authors\":\"Luc St-Onge , Fabienne Pituello , Peter Gruss\",\"doi\":\"10.1016/S1044-5781(06)80054-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Members of the <em>Pax</em> gene family exhibit distinct temporal and spatial expression patterns during murine embryogenesis. Their unique expression in the central nervous system implies a role in the regionalization of the spinal cord and early brain. <em>Pax</em> proteins are localized in the cell nucleus and possess a DNA-binding activity. This makes them good candidates for transcriptional regulator of developmental processes. Mutations in three <em>Pax</em> genes have been associated with three mouse mutants and two human diseases indicating that their activity is necessary for proper development of the embryo</p></div>\",\"PeriodicalId\":101155,\"journal\":{\"name\":\"Seminars in Developmental Biology\",\"volume\":\"6 4\",\"pages\":\"Pages 285-292\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1044-5781(06)80054-X\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in Developmental Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S104457810680054X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in Developmental Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S104457810680054X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Members of the Pax gene family exhibit distinct temporal and spatial expression patterns during murine embryogenesis. Their unique expression in the central nervous system implies a role in the regionalization of the spinal cord and early brain. Pax proteins are localized in the cell nucleus and possess a DNA-binding activity. This makes them good candidates for transcriptional regulator of developmental processes. Mutations in three Pax genes have been associated with three mouse mutants and two human diseases indicating that their activity is necessary for proper development of the embryo
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