实验室固体分散技术研究进展

Nikam Swati, Velhal Atish, Jadhav Prakash
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摘要

固体分散法是一种最古老、应用最广泛的方法,用于增加慢溶性物质的溶解度。固体分散体是利用多种药学上合适的成分和新工艺制备的。固体分散体是通过各种方法产生的,如捏合、共磨、熔融、溶剂蒸发和其他与溶剂有关的技术。选择合适的制造工艺和载体是生产具有良好稳定性和生物活性的均质产品的关键。本文综述了固体分散体的分类及其在提高溶解度方面的研究进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Review on Laboratory Scale Solid Dispersion Techniques
Solid Dispersion is one of the most ancient most extensively used procedures for increasing a slowly dissolving substance's solubility substances. Solid dispersion is prepared using a variety of pharmaceutically suitable ingredients and new technology. Solid dispersions were created through a variety of methods such as kneading, co-milling, fusing, solvent evaporation, and other solvent-related techniques. Choosing the right manufacturing technique and carrier is critical for producing a homogeneous product with good stability and biological activity. The review focuses on categorization of solid dispersion based on recent advancement and various techniques involved to improve solubility.
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