Non-Structural Proteases as a Target of Dengue Virus

Dengue is a globally emerging health concern, still in preliminary stage of drug development. Many research scientists explored the dengue virus and identified its several targets that are categorized as structural and non-structural proteins, irrespective of its serotypic classification. A number of natural, synthetic and patented analogs are screened and studied against different serotypes and targets of dengue. Our review compiles the recent developments based on the huge number of such molecular space created by diverse scaffolds, specifically targeting NS2B-NS3 protease and methyltransferase (NS5) of dengue virus (DENV) infection. The emphasis of our article is to confer the leads towards the DENV drug discovery.