E. Chuyan, M. Ravaeva, I. Cheretaev, Olga Kornilenko, Anastasia Furkovskaya, E. Birukova
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Bioscreening of the spacerized complex BIS (2-Pyridyl)-3-(1,2,4-Triazolyl) propane and 11-Hydroxy-1,1-Ethylidenediphosphonic acid
scientific work is devoted to the study of the biological activity spacerized complex bis(2-Pyridyl) -3(1,2,4Triazolyl) Propane And 11-Hydroxy-1,1Ethylidenediphosphonic Acid in the dose range from 5 to 200 mg / kg. The results of the study of acute toxicity showed that spacering of the HDA+BTP complex reduces its toxicity by 1.4 times in comparison with characteristics of its precursor components. It was found that the test compound exhibits a dose-dependent hypotensive and vasorelaxating effect, sedative, anxiogenic and analgesic effects. Keywords—spacerized complex bis (2-Pyridyl) -3(1,2,4Triazolyl) Propane and 11-Hydroxy-1,1-Ethylidenediphosphonic acid, bioscreening, rats
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