192ir高剂量率近距离放疗在结直肠癌术后复发肺内少转移的初步应用

Q4 Medicine
Yin Xiaoming, Sun Yun-chuan, H. Tingting, He Xinying, Bi Jianqiang, Xiao Li, Huang Rujing, Lu Hongling, Wang Junjie
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引用次数: 1

摘要

目的探讨192Ir高剂量率近距离放射治疗结直肠癌术后复发性肺内少转移的疗效和可行性。方法选取2013年5月至2017年10月沧州中西医结合医院大肠癌术后肺内少转移患者为研究对象。10例患者共获得15个病灶,采用ct引导下高剂量率192Ir治疗。将植入针插入肿瘤,在CT引导下调整到合适的位置。然后将移植后的图像上传到规划系统,以划定目标区域和危险器官体积。患者接受20 Gy的单次辐射剂量。结果10例患者均治疗成功。30%的患者出现1级不良事件。在这10名患者中,1名患者有轻微咳嗽,2名患者有带血痰。无严重不良事件发生。治疗1年后患者局部控制率(LC)为93.3%。6个月后,只有1例患者接受了二次近距离治疗,出现局部进展。中位无进展生存期(PFS)为8.5个月,中位总生存期(OS)为14.7个月。结论高剂量率近距离放疗对结直肠癌术后复发性肺转移瘤有较好的治疗效果,不良反应发生率适中,局部肿瘤控制率良好。关键词:结直肠癌;肺转移;高剂量率近距离放疗;192年红外
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Preliminary application of 192 Ir high-dose rate brachytherapy in postoperative recurrent colorectal cancer with intrapulmonary oligometastases
Objective To investigate the efficacy and feasibility of 192Ir high-dose rate brachytherapy for recurrent intrapulmonary oligometastasis after colorectal cancer surgery. Methods Patients from May 2013 to October 2017 with intrapulmonary oligometastasisafter colorectal cancer surgery in Cangzhou Integrated Traditional Chinese and Western Medicine Hospital were enrolled. A total of 15 lesions were obtained from 10 patients, which were treated with CT-guided high dose rate of 192Ir. The implant needles were inserted into the tumor and were adjusted to appropriate positions under the guidance of CT. Then the images after transplanting were uploaded to the planning system to delineate the target area and the organ at risk volume. Patients underwent a single radiation dose of 20 Gy. Results All 10 patients were successfully treated. Grade 1 adverse events were observed for 30% of patients. Of the 10 patients, one patient had a mild cough, and two had bloody sputum. There was no serious adverse events occurred. The local control rate (LC) of the patients at 1 year after treatment was achieved in 93.3%. Only one developed local advancement after six months, who received the secondary brachytherapy. The median progression-free survival(PFS) was 8.5 months and the median overall survival(OS) was 14.7 months. Conclusions High dose rate brachytherapy is effective in terms of recurrent lung metastases after surgery for colorectal cancer, with a moderate rate of adverse reactions and a favorable local tumor control rate. Key words: Colorectal cancer; Lung metastasis; High dose ratebrachytherapy; 192Ir
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来源期刊
中华放射医学与防护杂志
中华放射医学与防护杂志 Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.60
自引率
0.00%
发文量
6377
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