Novel Health Functions of Aloe Vera Gel-derived Phytosterols and Their Application in Functional Foods

Summary : We have identified five phytosterols （ Aloe sterols ） obtained from Aloe vera gel as functional ingredients. In this study, we investigated the effects of orally ingested Aloe sterols on skin function, which is impor-tant for body homeostasis. In an in vitro study, the synthesis and production of collagen and hyaluronan by fibroblasts isolated from human skin were stimulated by addition of Aloe sterols. Aloe sterol supplementation in vivo also suppressed UV-induced reductions of skin hydration, elasticity and dermal collagen content signifi-cantly. We then performed a 12 -week double blind, randomized controlled trial of daily oral intake of Aloe sterols, and observed significant increases in skin barrier function, skin moisture, skin elasticity and dermal collagen content. The results of these studies confirmed the usefulness of Aloe sterols as functional food material for maintenance and promotion of skin health.