http://ukrbiochemjournal.org/2022/12/changes-in-the-activity-of-phosphatases-calcium-and-phosphorus-in-rats-with-the-different-courses-of-gingivitis-under-correction-by-anti-inflammatory-gel.html

M. Danchyshyn, O. Lototska
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引用次数: 0

摘要

近年来,地下水硝酸盐污染日益严重。本研究的目的是研究大鼠在饮用不同硝酸盐含量的饮用水时骨髓的形态学特征。实验选用2组不同年龄(成熟和未成熟)的雌性白鼠,每组30只。两组老鼠被分成5个亚组,每个亚组老鼠自己饮用的饮用水质量不同。在为期30天的研究中,研究人员以每升50、150、250、500毫克硝酸钠的剂量给老鼠饮用硝酸盐。对照组的动物从城市供水系统中饮水。通过形态学分析评价硝酸盐对大鼠骨髓的影响。研究发现,饮用含硝酸盐的饮用水会影响红细胞和白细胞的生成,表现为母细胞、淋巴细胞、原造血细胞和正常细胞、巨核细胞和嗜酸性粒细胞的生长,红细胞芽细胞的移位。中性粒细胞成熟指数的增加表明中性粒细胞成熟延迟,骨髓成熟细胞产量增加,粒细胞谱系耗竭。红细胞芽的成分在定性和定量上的变化更为明显。这些疾病是剂量依赖性的,在未成熟动物组中,剂量为250和500 mg/l的硝酸盐会增加血液毒性作用,并导致骨髓的变化,这可能进一步导致生物体病理过程的发展。关键词:大鼠骨髓,饮用水,硝酸盐,Van Gieson染色
本文章由计算机程序翻译,如有差异,请以英文原文为准。
http://ukrbiochemjournal.org/2022/12/changes-in-the-activity-of-phosphatases-calcium-and-phosphorus-in-rats-with-the-different-courses-of-gingivitis-under-correction-by-anti-inflammatory-gel.html
Nitrate pollution of groundwater has been increasing in recent years. The aim of this work was to study the morphological features of the bone marrow of rats at the consumption of drinking water with varying nitrate content. The experiment was performed on 2 groups of white female rats of different ages (mature and immature) with 30 individuals each. Both groups were divided into 5 subgroups that differed in the quality of drinking water consumed by rats on their own. In the 30 days study, nitrate was given to rats in drinking water in doses of 50, 150, 250, 500 mg of sodium nitrate per liter. Animals of the control group drank water from the city water supply. The effect of nitrates on the bone marrow of rats was evaluated by morphological analysis. It was found that the consumption of drinking water with nitrates affected erythropoiesis and leukopoiesis, as evidenced by the growth of blasts, lymphocytes, pronormocytes and normocytes, megakaryocytes and eosinophils, displacement of erythrocyte sprout cells. An increase in the neutrophil maturation index indicates delayed neutrophil maturation, increased yield of mature cells from the bone marrow and depletion of the granulocyte lineage. The more pronounced changes were observed in the qualitative and quantitative composition of the components of the erythrocyte sprout. These disorders were dose-dependent with increasing hematotoxic effect of nitrates at doses of 250 and 500 mg/l in the group of immature animals and resulted in changes in the bone marrow, which may further cause the development of pathological processes in an organism. Keywords: bone marrow of rats, drinking water, nitrates, Van Gieson’s stain
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