刘以训 杜群 刘奎 周红明 胡召元, Du Qun Liu Kui Zhou Gong-Meng Hu Shao-Yuan Liu Si-Xun
{"title":"Sertoli和Leydig细胞的相互作用及其PA/PAI-1表达的调节","authors":"刘以训 杜群 刘奎 周红明 胡召元, Du Qun Liu Kui Zhou Gong-Meng Hu Shao-Yuan Liu Si-Xun","doi":"10.1360/ZB1995-25-8-852","DOIUrl":null,"url":null,"abstract":"用细胞培养,SDS-凝胶电泳,纤蛋白铺盖和反向纤蛋白自显影等技术研究了大鼠睾丸支持细胞(Sc)和间质细胞(Lc)的相互作用。实验结果表明,Sc产生两种纤溶酶原激活因子(PA),即组织型PA(tPA)和尿激酶型PA(uPA)及一种PA的抑制因子(PAI-1)。tPA及PAI-1的分泌受FSH,forskolin(FK)。双丁酰环腺苷酸(dbcAMP),GnRH及生长因子(EGF,FGF)的调节;但不受hCG和雄烯二酮(△~4)的影响;FSH也刺激Sc产生PAI-1。本项研究证明大鼠Sc能同时产生tPA,uPA和PAI-1;而Lc和Sc的相互作用是tPA和PAI-1表达的重要条件。","PeriodicalId":21648,"journal":{"name":"Science in China. Series B, Chemistry, life sciences & earth sciences","volume":"104 1","pages":"852-857"},"PeriodicalIF":0.0000,"publicationDate":"1995-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sertoli和Leydig细胞的相互作用及其PA/PAI-1表达的调节\",\"authors\":\"刘以训 杜群 刘奎 周红明 胡召元, Du Qun Liu Kui Zhou Gong-Meng Hu Shao-Yuan Liu Si-Xun\",\"doi\":\"10.1360/ZB1995-25-8-852\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"用细胞培养,SDS-凝胶电泳,纤蛋白铺盖和反向纤蛋白自显影等技术研究了大鼠睾丸支持细胞(Sc)和间质细胞(Lc)的相互作用。实验结果表明,Sc产生两种纤溶酶原激活因子(PA),即组织型PA(tPA)和尿激酶型PA(uPA)及一种PA的抑制因子(PAI-1)。tPA及PAI-1的分泌受FSH,forskolin(FK)。双丁酰环腺苷酸(dbcAMP),GnRH及生长因子(EGF,FGF)的调节;但不受hCG和雄烯二酮(△~4)的影响;FSH也刺激Sc产生PAI-1。本项研究证明大鼠Sc能同时产生tPA,uPA和PAI-1;而Lc和Sc的相互作用是tPA和PAI-1表达的重要条件。\",\"PeriodicalId\":21648,\"journal\":{\"name\":\"Science in China. Series B, Chemistry, life sciences & earth sciences\",\"volume\":\"104 1\",\"pages\":\"852-857\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1995-08-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science in China. Series B, Chemistry, life sciences & earth sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1360/ZB1995-25-8-852\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science in China. Series B, Chemistry, life sciences & earth sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1360/ZB1995-25-8-852","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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