Acetylcholine receptors antibodies in postural tachycardia syndrome

Postural tachycardia syndrome (POTS) is a type of chronic orthostatic intolerance. Acetylcholine receptor antibodies (AChR-ab) mediated autonomic dysfunction is common in POTS patients. Therefore, it is important to explore the value of serum AChR-ab in those patients. In a recent paper published in Pediatric Cardiology, we compared POTS patients with different AChR-ab status and found preceding infection, syncope and fatigue as main clinical features of POTS patients with AChR-ab positive. Thus, clinicians can determine targeted therapy of acetylcholinesterase inhibitors or immunotherapy according to both the specific clinical features and the results of AChR-ab detecting.