非线性时间反转声学的医学应用前景

A. Sutin, H. Salloum
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引用次数: 5

摘要

时间反转声学(TRA)聚焦方法为选定的身体区域提供精确的聚焦和声能,这些方法的各种医学应用正在研究中。在这里,我们考虑了非线性效应在TRA中的三种潜在应用。其中两种药物的初步实验是在几年前进行的,但没有发表。第三种新的方法将TRA聚焦与超声造影剂(UCA)的非线性声学成像相结合,用于以下应用:非线性TRA方法直接测量血流中的血压。这种方法是基于对注射在血液中的超声造影剂的二次谐波信号的测量。2. 非线性TRA用于骨质疏松评估。这是基于两种不同频率信号的声能在一小块骨头中的集中。测量是用频率总和的信号进行的。用人类跟骨样本进行了测试。3.非线性TRA聚焦于UCA,精确治疗靶区,增强药物和基因传递。该方法是基于UCA接收非线性散射信号并对其进行频率变换,并将传输信号应用于TRA聚焦。时间反转声学(TRA)聚焦方法为选定的身体区域提供精确的聚焦和声能,这些方法的各种医学应用正在研究中。在这里,我们考虑了非线性效应在TRA中的三种潜在应用。其中两种药物的初步实验是在几年前进行的,但没有发表。第三种新的方法将TRA聚焦与超声造影剂(UCA)的非线性声学成像相结合,用于以下应用:非线性TRA方法直接测量血流中的血压。这种方法是基于对注射在血液中的超声造影剂的二次谐波信号的测量。2. 非线性TRA用于骨质疏松评估。这是基于两种不同频率信号的声能在一小块骨头中的集中。测量是用频率总和的信号进行的。测试是用人类跟骨样本. ...进行的
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prospective medical applications of Nonlinear Time Reversal Acoustics
Time Reversal Acoustic (TRA) focusing methods provide precise focusing and acoustic energy to chosen areas of the body, where various medical applications of these methods are under investigation. Here, we consider three prospective applications of the Nonlinear effects in TRA. Preliminary experiments for two of them were conducted several years ago, but were not published. A new third method combines TRA focusing with nonlinear acoustic imaging of ultrasonic contrast agents (UCA) for the following applications: 1. Nonlinear TRA method for blood pressure measurements directly in the blood stream. This method is based on the measurement of the second harmonic signal from an Ultrasonic Contrast Agent injected in the blood. 2. Nonlinear TRA for osteoporosis assessment. This is based on the concentration of acoustic energy of two signals with different frequencies in a small volume of bone. Measurements are made with a signal that sums the frequencies. Tests were conducted with a human calcanei bone sample. 3. Nonlinear TRA focusing to UCA for precise treatment of target areas and enhancement drug and gene delivery. This method is based on the reception of signals of nonlinear scattering from UCA and their frequency transformation and application of transferred signals for TRA focusing. Time Reversal Acoustic (TRA) focusing methods provide precise focusing and acoustic energy to chosen areas of the body, where various medical applications of these methods are under investigation. Here, we consider three prospective applications of the Nonlinear effects in TRA. Preliminary experiments for two of them were conducted several years ago, but were not published. A new third method combines TRA focusing with nonlinear acoustic imaging of ultrasonic contrast agents (UCA) for the following applications: 1. Nonlinear TRA method for blood pressure measurements directly in the blood stream. This method is based on the measurement of the second harmonic signal from an Ultrasonic Contrast Agent injected in the blood. 2. Nonlinear TRA for osteoporosis assessment. This is based on the concentration of acoustic energy of two signals with different frequencies in a small volume of bone. Measurements are made with a signal that sums the frequencies. Tests were conducted with a human calcanei bone sample. ...
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