Tatiana Kotova, Anastasia S. Valnyukova, Yu. B. Fedorova, Konstantin A. Khudyntsev, N. Bhatia, Grigory Zornichenko
{"title":"西伯利亚冷杉油馏分化学成分、抑菌活性及急性毒性的筛选研究","authors":"Tatiana Kotova, Anastasia S. Valnyukova, Yu. B. Fedorova, Konstantin A. Khudyntsev, N. Bhatia, Grigory Zornichenko","doi":"10.29141/2500-1922-2023-8-2-10","DOIUrl":null,"url":null,"abstract":"Siberian fir is a common species in the taiga zones. A man produces oils, balms, extracts, cell sap, phytoconcentrates, syrups, etc., used in the food, phar-maceutical, perfume and cosmetic industries, in the household chemicals produc-tion and in medicine from the waste left after harvesting the wood. Siberian fir waste processing products have antioxidant and anti-inflammatory properties and can be components of the biologically active additives and functional prod-ucts manufacture. The research aims at studying chemical composition of biologically active substances, macro- and microelements, as well as the antibacterial activity and toxicity of the oil fraction obtained from Siberian fir. The study ob-ject is the oil fraction obtained from the Siberian fir extract by extraction with liquid carbon dioxide. A man run screening and identification of target biologically active substances using methods of analytical HELC, IR spectroscopy (IR), gas-liquid chromatography-mass spectrometry (GLC-MS). The researchers de-termined antibacterial activity of the samples in relation to ten clinical microor-ganism isolates by the agar diffusion method. They studied toxicity on outbred mice, males and females CD-I at doses of 2.5, 1.25, 0.625 g/kg animal weight. The thesis consists of microbiological parameters of Siberian fir extract; experi-mental data on the qualitative and quantitative content of biologically active sub-stances, macro- and microelements in the oil fraction of Siberian fir. The study results of the oil fraction indicate that it is a rich source of biologically active sub-stances with antioxidant and anti-inflammatory properties; it belongs to the third hazard class (moderately dangerous substances). Microbiological indicators are within the permissible norm. The oil fraction of Siberian fir extract can be rec-ommended in the production of biologically active additives, functional products, but only after deep processing associated with the components fractionation of the raw materials used.","PeriodicalId":7684,"journal":{"name":"Agro Food Industry Hi-tech","volume":"19 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Screening Studies of Chemical Composition, Antibacterial Activity and Acute Toxicity of Siberian Fir Oil Fraction\",\"authors\":\"Tatiana Kotova, Anastasia S. Valnyukova, Yu. B. Fedorova, Konstantin A. Khudyntsev, N. Bhatia, Grigory Zornichenko\",\"doi\":\"10.29141/2500-1922-2023-8-2-10\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Siberian fir is a common species in the taiga zones. A man produces oils, balms, extracts, cell sap, phytoconcentrates, syrups, etc., used in the food, phar-maceutical, perfume and cosmetic industries, in the household chemicals produc-tion and in medicine from the waste left after harvesting the wood. Siberian fir waste processing products have antioxidant and anti-inflammatory properties and can be components of the biologically active additives and functional prod-ucts manufacture. The research aims at studying chemical composition of biologically active substances, macro- and microelements, as well as the antibacterial activity and toxicity of the oil fraction obtained from Siberian fir. The study ob-ject is the oil fraction obtained from the Siberian fir extract by extraction with liquid carbon dioxide. A man run screening and identification of target biologically active substances using methods of analytical HELC, IR spectroscopy (IR), gas-liquid chromatography-mass spectrometry (GLC-MS). The researchers de-termined antibacterial activity of the samples in relation to ten clinical microor-ganism isolates by the agar diffusion method. They studied toxicity on outbred mice, males and females CD-I at doses of 2.5, 1.25, 0.625 g/kg animal weight. The thesis consists of microbiological parameters of Siberian fir extract; experi-mental data on the qualitative and quantitative content of biologically active sub-stances, macro- and microelements in the oil fraction of Siberian fir. The study results of the oil fraction indicate that it is a rich source of biologically active sub-stances with antioxidant and anti-inflammatory properties; it belongs to the third hazard class (moderately dangerous substances). Microbiological indicators are within the permissible norm. The oil fraction of Siberian fir extract can be rec-ommended in the production of biologically active additives, functional products, but only after deep processing associated with the components fractionation of the raw materials used.\",\"PeriodicalId\":7684,\"journal\":{\"name\":\"Agro Food Industry Hi-tech\",\"volume\":\"19 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-06-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Agro Food Industry Hi-tech\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.29141/2500-1922-2023-8-2-10\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q\",\"JCRName\":\"Engineering\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Agro Food Industry Hi-tech","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29141/2500-1922-2023-8-2-10","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q","JCRName":"Engineering","Score":null,"Total":0}
Screening Studies of Chemical Composition, Antibacterial Activity and Acute Toxicity of Siberian Fir Oil Fraction
Siberian fir is a common species in the taiga zones. A man produces oils, balms, extracts, cell sap, phytoconcentrates, syrups, etc., used in the food, phar-maceutical, perfume and cosmetic industries, in the household chemicals produc-tion and in medicine from the waste left after harvesting the wood. Siberian fir waste processing products have antioxidant and anti-inflammatory properties and can be components of the biologically active additives and functional prod-ucts manufacture. The research aims at studying chemical composition of biologically active substances, macro- and microelements, as well as the antibacterial activity and toxicity of the oil fraction obtained from Siberian fir. The study ob-ject is the oil fraction obtained from the Siberian fir extract by extraction with liquid carbon dioxide. A man run screening and identification of target biologically active substances using methods of analytical HELC, IR spectroscopy (IR), gas-liquid chromatography-mass spectrometry (GLC-MS). The researchers de-termined antibacterial activity of the samples in relation to ten clinical microor-ganism isolates by the agar diffusion method. They studied toxicity on outbred mice, males and females CD-I at doses of 2.5, 1.25, 0.625 g/kg animal weight. The thesis consists of microbiological parameters of Siberian fir extract; experi-mental data on the qualitative and quantitative content of biologically active sub-stances, macro- and microelements in the oil fraction of Siberian fir. The study results of the oil fraction indicate that it is a rich source of biologically active sub-stances with antioxidant and anti-inflammatory properties; it belongs to the third hazard class (moderately dangerous substances). Microbiological indicators are within the permissible norm. The oil fraction of Siberian fir extract can be rec-ommended in the production of biologically active additives, functional products, but only after deep processing associated with the components fractionation of the raw materials used.