西伯利亚冷杉油馏分化学成分、抑菌活性及急性毒性的筛选研究

Q Engineering
Tatiana Kotova, Anastasia S. Valnyukova, Yu. B. Fedorova, Konstantin A. Khudyntsev, N. Bhatia, Grigory Zornichenko
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引用次数: 0

摘要

西伯利亚冷杉是针叶林地带常见的树种。一个人从收获木材后留下的废料中生产油、香脂、提取物、细胞汁液、植物浓缩物、糖浆等,用于食品、制药、香水和化妆品工业、家用化学品生产和药品。西伯利亚冷杉废弃物加工产品具有抗氧化和抗炎的特性,可作为生物活性添加剂的组成部分和功能性产品的制造。本研究旨在研究西伯利亚杉木油馏分的生物活性物质的化学组成、宏量元素和微量元素,以及抑菌活性和毒性。以西伯利亚冷杉提取物为研究对象,采用液体二氧化碳萃取法提取油分。利用HELC、IR、气相色谱-质谱(GLC-MS)等分析方法对目标生物活性物质进行筛选和鉴定。研究人员通过琼脂扩散法确定了样品与十种临床微生物分离物的抗菌活性。他们研究了CD-I在2.5、1.25、0.625 g/kg动物体重剂量下对远交种小鼠、雄性和雌性的毒性。本文主要包括西伯利亚冷杉提取物的微生物学参数;西伯利亚冷杉油分中生物活性物质、宏量元素和微量元素定性定量含量的实验数据。研究结果表明,其油馏分富含抗氧化、抗炎等生物活性物质;属于第三类危害(中度危险物质)。微生物指标在允许范围内。西伯利亚冷杉提取物的油分可推荐用于生产生物活性添加剂、功能性产品,但必须经过与原料成分分馏相关的深加工。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Screening Studies of Chemical Composition, Antibacterial Activity and Acute Toxicity of Siberian Fir Oil Fraction
Siberian fir is a common species in the taiga zones. A man produces oils, balms, extracts, cell sap, phytoconcentrates, syrups, etc., used in the food, phar-maceutical, perfume and cosmetic industries, in the household chemicals produc-tion and in medicine from the waste left after harvesting the wood. Siberian fir waste processing products have antioxidant and anti-inflammatory properties and can be components of the biologically active additives and functional prod-ucts manufacture. The research aims at studying chemical composition of biologically active substances, macro- and microelements, as well as the antibacterial activity and toxicity of the oil fraction obtained from Siberian fir. The study ob-ject is the oil fraction obtained from the Siberian fir extract by extraction with liquid carbon dioxide. A man run screening and identification of target biologically active substances using methods of analytical HELC, IR spectroscopy (IR), gas-liquid chromatography-mass spectrometry (GLC-MS). The researchers de-termined antibacterial activity of the samples in relation to ten clinical microor-ganism isolates by the agar diffusion method. They studied toxicity on outbred mice, males and females CD-I at doses of 2.5, 1.25, 0.625 g/kg animal weight. The thesis consists of microbiological parameters of Siberian fir extract; experi-mental data on the qualitative and quantitative content of biologically active sub-stances, macro- and microelements in the oil fraction of Siberian fir. The study results of the oil fraction indicate that it is a rich source of biologically active sub-stances with antioxidant and anti-inflammatory properties; it belongs to the third hazard class (moderately dangerous substances). Microbiological indicators are within the permissible norm. The oil fraction of Siberian fir extract can be rec-ommended in the production of biologically active additives, functional products, but only after deep processing associated with the components fractionation of the raw materials used.
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来源期刊
Agro Food Industry Hi-tech
Agro Food Industry Hi-tech 工程技术-生物工程与应用微生物
CiteScore
0.29
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0.00%
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0
审稿时长
6-12 weeks
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