类固醇激素和激素特异性自身抗体在乳腺癌进展中的协同作用

Fundamental and Clinical Medicine Pub Date : 2023-06-29 DOI:10.23946/2500-0764-2023-8-2-19-32

A. Glushkov, E. Polenok, S. Mun, L. Gordeeva, M. Kostyanko, A. Antonov, P. V. Bayramov, N. Verzhbitskaya, G. Kolpinskiy

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Simultaneous increase in IgA1-E2 and IgG2-E2 levels was associated with elevated E2 serum concentration (p = 0.007) in ER+/PR+ breast cancer patients. On the contrary, concurrent increase in IgA1-Pg и IgG2-Pg, was associated with lowered Pg concentration (p = 0.04). The frequency of ER+/PR+ tumors was low and ER-/PR- was high in patients with stages 2-4 breast cancer than in stage 1 in the following cases: 1) IgG2-E2 and IgA1-E2 levels were high regardless of serum E2 (p = 0.004); 2) IgG2-E2 levels were high and IgA1-E2 and E2 levels were low (p = 0.002); 3) IgG2-Pg and Pg levels were high regardless of IgA1-Pg levels (р < 0,001); 4) IgG2-E2 and IgG2-Pg levels were high regardless of E2, Pg, IgA1-E2 and IgA1-Pg levels (р < 0,001). In other combinations of hormones and hormone-specific antibodies and anti-antibodies, there have been no differences in the frequency of ER+/PR+ and ER-/PR- tumors between patients with ascending stages of breast cancer.Conclusion. 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引用次数: 0

摘要

的目标。探讨类固醇激素与激素特异性自身抗体及抗自身抗体在乳腺癌患者ER+/PR+肿瘤向ER-/PR-转化过程中可能的协同作用。材料与方法。采用酶联免疫吸附法对979例乳腺癌患者(1期432例，2-4期547例)血清中雌二醇(E2)、孕酮(Pg)浓度及激素特异性独特型IgA抗体(IgA1-E2和IgA1-Pg)和抗独特型IgG抗体(IgG2-E2和IgG2-Pg)水平进行了检测。免疫组织化学法测定E2和Pg受体表型(ER/ PR)。在ER+/PR+乳腺癌患者中，IgA1-E2和IgG2-E2水平同时升高与E2血清浓度升高相关(p = 0.007)。相反，IgA1-Pg和IgG2-Pg同时升高与Pg浓度降低相关(p = 0.04)。2 ~ 4期乳腺癌患者ER+/PR+肿瘤发生率低于1期，ER-/PR-肿瘤发生率高于1期:1)无论血清E2水平如何，IgG2-E2和IgA1-E2水平均较高(p = 0.004);2) IgG2-E2水平高，IgA1-E2和E2水平低(p = 0.002);3)与IgA1-Pg水平无关，IgG2-Pg和Pg水平均较高(p < 0.01);4)与E2、Pg、IgA1-E2和IgA1-Pg水平无关，IgG2-E2和IgG2-Pg水平均较高(p < 0.001)。在其他激素及激素特异性抗体和抗抗体的联合使用中，乳腺癌升期患者ER+/PR+和ER-/PR-肿瘤的发生频率无差异。我们首次发现激素特异性独特型和抗独特型自身抗体对乳腺癌患者血清中类固醇激素浓度的协同作用，以及类固醇激素与激素特异性独特型和抗独特型自身抗体对肿瘤类固醇受体转化的协同作用。

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Synergistic action of steroid hormones and hormone-specific autoantibodies in breast cancer progression

Aim. To study the possible synergistic action of steroid hormones and hormone-specific autoantibodies and anti-autoantibodies in conversion of ER+/PR+ tumors into ER-/PR- in breast cancer patients.Materials and Methods. Concentrations of estradiol (E2) and progesterone (Pg) and the levels of hormone-specific idiotypic IgA antibodies (IgA1-E2 and IgA1-Pg) as well as anti-idiotypic IgG antibodies (IgG2-E2 and IgG2-Pg) were studied in the serum of 979 breast cancer patients (432 patients with stage 1 and 547 patients with stages 2-4) by means of enzyme-linked immunosorbent assay. E2 and Pg receptors phenotype (ER/ PR) was determined using immunohistochemistry.Results. Simultaneous increase in IgA1-E2 and IgG2-E2 levels was associated with elevated E2 serum concentration (p = 0.007) in ER+/PR+ breast cancer patients. On the contrary, concurrent increase in IgA1-Pg и IgG2-Pg, was associated with lowered Pg concentration (p = 0.04). The frequency of ER+/PR+ tumors was low and ER-/PR- was high in patients with stages 2-4 breast cancer than in stage 1 in the following cases: 1) IgG2-E2 and IgA1-E2 levels were high regardless of serum E2 (p = 0.004); 2) IgG2-E2 levels were high and IgA1-E2 and E2 levels were low (p = 0.002); 3) IgG2-Pg and Pg levels were high regardless of IgA1-Pg levels (р < 0,001); 4) IgG2-E2 and IgG2-Pg levels were high regardless of E2, Pg, IgA1-E2 and IgA1-Pg levels (р < 0,001). In other combinations of hormones and hormone-specific antibodies and anti-antibodies, there have been no differences in the frequency of ER+/PR+ and ER-/PR- tumors between patients with ascending stages of breast cancer.Conclusion. We for the first time found a synergistic action of hormone-specific idiotypic and anti-idiotypic autoantibodies on the concentration of steroid hormones in the serum of breast cancer patients, and the synergistic action of steroid hormones and hormone-specific idiotypic and anti-idiotypic autoantibodies on tumor steroid receptor conversion.

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Fundamental and Clinical Medicine

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