阿立哌唑的药物评价对现代研究的帮助:一个乐观的回顾

P. Jain, Santosh B. Bodkhe, Urmila R. Salunke, N. G. Haswani
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引用次数: 0

摘要

阿立哌唑是第二代抗精神病药物。之前已经发表了大量的调查;说明分析方法。本报告报道了阿立哌唑在其医学制剂和生物基质中的调查。概述了分析中应用最广泛的方法,如光谱法、液相色谱法、液相色谱-质谱法、伏安法和气相色谱法(GC)。精确地说明了单独和联合使用ARP的光谱测定方法。其中包括如下参数:以表格形式给出了阿立哌唑单药和复方阿立哌唑的HPLC测定方法、基质、固定相、流动相组成、检测波长等参数。以表格形式报道了hplc方法,包括流动相组合、固定相、Rf等参数。本文详细介绍了2004 - 2019年发表的阿立哌唑及其代谢物的色谱-质谱分析方法,包括基质、固定相、流动相、内标、流速、保留时间等参数,并对这些方法对阿立哌唑的测定效果进行了统计分析,为今后进一步的分析和处方研究提供参考。关键词:阿立哌唑,药物,分析方法,应用,范围,综述
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pharmaceutical estimation of aripiprazole to assist in modern research: An upbeat review
Aripiprazole is second generation anti-psychotic drug. Numerous investigations that have been published previously; stating analytical methods. The reported investigations for aripiprazole in its medical preparation and biological matrices is in present report. The most widely employed approaches in analysis outlined, such as spectrometric, liquid chromatographic processes, liquid chromatography-mass spectrometry, voltammetry and gas chromatography (GC). Spectrometric methods for ARP alone and in combination are precisely stated. Which includes parameters like ? max, solvent, matrix etc. and HPLC methods for aripiprazole single and in combination are given in tabular form, to parameters like matrix, stationary phase, mobile phase composition detection wavelength etc. HPTLC methods are reported in tabular form contain parameters like mobile phase combination, stationary phase, Rf etc. LC-MS method of aripiprazole and metabolite including parameter like matrix, stationary phase, mobile phase, internal standard, flow rate, retention time etc. the statistical data regarding the utility of these methods for estimation of aripiprazole published during 2004 to 2019 is precisely presented herein assist in further analytical and formulation research in future. Keywords: Aripiprazole, Pharmaceutical, Analytical methods, Applications, Scope, Review.
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