{"title":"胡志明市大学医学中心骨转换标志物参考数据库","authors":"Thanh Cao Ngoc, Thuy Tran Hong","doi":"10.34071/jmp.2023.2.13","DOIUrl":null,"url":null,"abstract":"Objectives: To establish reference ranges for serum bone turnover markers including Osteocalcin (OC), Procollagen type 1 amino-terminal propeptide (P1NP), and Beta-CrossLaps (beta-CTX) in premenopausal women at University Medical Center, Ho Chi Minh City.\n\nMethods: A cross-sectional study was conducted on 157 women aged 20 to 44 years at University Medical Center, Ho Chi Minh City from December 2022 to February 2023. Demographic information, biochemical markers, and serum levels of OC, P1NP, and beta-CTX were recorded.\n\nResults: The mean serum levels of OC, P1NP, and beta-CTX were 15.57 ± 4.75 ng/mL, 41.98 ± 16.62 μg/L, and 314.03 ± 150.42 pg/mL, respectively. The levels of bone turnover markers varied significantly among different age groups (p < 0.01). Serum levels of OC, P1NP, and beta-CTX were negatively correlated with age, with r values of -0.44, -0.35 and -0.43 respectively (p < 0.01).\n\nConclusion: The reference ranges for serum markers of bone turnover including OC, P1NP, and beta-CTX were 15.57 ± 4.75 ng/mL, 41.98 ± 16.62 μg/L, and 314.03 ± 150.42 pg/mL, respectively, in premenopausal women aged 20 to 44 years. Serum levels of OC, P1NP, and beta-CTX were negatively correlated with age in a moderate degree\n\nKey words: osteocalcin, P1NP, beta-CTX, bone turnover markers, premenopausal women.","PeriodicalId":86274,"journal":{"name":"The South Dakota journal of medicine and pharmacy","volume":"2 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Bone turnover markers reference database at University Medical Center, Ho Chi Minh city\",\"authors\":\"Thanh Cao Ngoc, Thuy Tran Hong\",\"doi\":\"10.34071/jmp.2023.2.13\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objectives: To establish reference ranges for serum bone turnover markers including Osteocalcin (OC), Procollagen type 1 amino-terminal propeptide (P1NP), and Beta-CrossLaps (beta-CTX) in premenopausal women at University Medical Center, Ho Chi Minh City.\\n\\nMethods: A cross-sectional study was conducted on 157 women aged 20 to 44 years at University Medical Center, Ho Chi Minh City from December 2022 to February 2023. Demographic information, biochemical markers, and serum levels of OC, P1NP, and beta-CTX were recorded.\\n\\nResults: The mean serum levels of OC, P1NP, and beta-CTX were 15.57 ± 4.75 ng/mL, 41.98 ± 16.62 μg/L, and 314.03 ± 150.42 pg/mL, respectively. The levels of bone turnover markers varied significantly among different age groups (p < 0.01). Serum levels of OC, P1NP, and beta-CTX were negatively correlated with age, with r values of -0.44, -0.35 and -0.43 respectively (p < 0.01).\\n\\nConclusion: The reference ranges for serum markers of bone turnover including OC, P1NP, and beta-CTX were 15.57 ± 4.75 ng/mL, 41.98 ± 16.62 μg/L, and 314.03 ± 150.42 pg/mL, respectively, in premenopausal women aged 20 to 44 years. Serum levels of OC, P1NP, and beta-CTX were negatively correlated with age in a moderate degree\\n\\nKey words: osteocalcin, P1NP, beta-CTX, bone turnover markers, premenopausal women.\",\"PeriodicalId\":86274,\"journal\":{\"name\":\"The South Dakota journal of medicine and pharmacy\",\"volume\":\"2 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The South Dakota journal of medicine and pharmacy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.34071/jmp.2023.2.13\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The South Dakota journal of medicine and pharmacy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34071/jmp.2023.2.13","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Bone turnover markers reference database at University Medical Center, Ho Chi Minh city
Objectives: To establish reference ranges for serum bone turnover markers including Osteocalcin (OC), Procollagen type 1 amino-terminal propeptide (P1NP), and Beta-CrossLaps (beta-CTX) in premenopausal women at University Medical Center, Ho Chi Minh City.
Methods: A cross-sectional study was conducted on 157 women aged 20 to 44 years at University Medical Center, Ho Chi Minh City from December 2022 to February 2023. Demographic information, biochemical markers, and serum levels of OC, P1NP, and beta-CTX were recorded.
Results: The mean serum levels of OC, P1NP, and beta-CTX were 15.57 ± 4.75 ng/mL, 41.98 ± 16.62 μg/L, and 314.03 ± 150.42 pg/mL, respectively. The levels of bone turnover markers varied significantly among different age groups (p < 0.01). Serum levels of OC, P1NP, and beta-CTX were negatively correlated with age, with r values of -0.44, -0.35 and -0.43 respectively (p < 0.01).
Conclusion: The reference ranges for serum markers of bone turnover including OC, P1NP, and beta-CTX were 15.57 ± 4.75 ng/mL, 41.98 ± 16.62 μg/L, and 314.03 ± 150.42 pg/mL, respectively, in premenopausal women aged 20 to 44 years. Serum levels of OC, P1NP, and beta-CTX were negatively correlated with age in a moderate degree
Key words: osteocalcin, P1NP, beta-CTX, bone turnover markers, premenopausal women.
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