离子通道目标的验证

IF 3.3 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Channels Pub Date : 2015-11-02 DOI:10.1080/19336950.2015.1081725

A. Gerlach, Brett M. Antonio

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引用次数: 8

摘要

一个成功的基于靶标的药物发现计划的先决条件是一个强大的数据集，以增加对分子靶标和治疗方法验证的信心。考虑到将药物推向市场需要大量的时间和资源投资，早期选择可以安全有效地调节的靶点构成了强大的组合和管道的基础。在本文中，我们介绍了一些更有用的科学方法，可以应用于离子通道靶点的验证，离子通道靶点是一个分子家族，在心血管、呼吸、疼痛和神经科学等治疗领域具有临床成功的历史。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Validation of ion channel targets

A prerequisite for a successful target-based drug discovery program is a robust data set that increases confidence in the validation of the molecular target and the therapeutic approach. Given the significant time and resource investment required to carry a drug to market, early selection of targets that can be modulated safely and effectively forms the basis for a strong portfolio and pipeline. In this article we present some of the more useful scientific approaches that can be applied toward the validation of ion channel targets, a molecular family with a history of clinical success in therapeutic areas such as cardiovascular, respiratory, pain and neuroscience.

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来源期刊

Channels 生物-生化与分子生物学

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Channels is an open access journal for all aspects of ion channel research. The journal publishes high quality papers that shed new light on ion channel and ion transporter/exchanger function, structure, biophysics, pharmacology, and regulation in health and disease. Channels welcomes interdisciplinary approaches that address ion channel physiology in areas such as neuroscience, cardiovascular sciences, cancer research, endocrinology, and gastroenterology. Our aim is to foster communication among the ion channel and transporter communities and facilitate the advancement of the field.