兔cathepsin d和e胰岛素链b的特异性研究

H. Rangel , C. Lapresle
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引用次数: 7

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Etude de la specificite sur la chaine b de l'insuline des cathepsines d et e de lapin

The action of rabbit cathepsins D and E on the B chain of beef insulin has been studied.

Cathepsin D hydrolyses the bonds Leu11-Val12, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Leu17-Val18, Phe24-Phe25, Phe25-Tyr26, Tyr26-Thr27. Furthermore, it hydrolyses one of the bonds His5-Leu6 or Leu6-Cys7, or both.

Cathepsin E hydrolyses the bonds Leu11-Val12, Glu13-Val14, Leu15-Tyr16, Tyr16-Leu17, Phe24-Phe25, Phe25-Tyr26.

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