Study of the effect of prostaglandin analogs on the periorbita of glaucomatous patients

Objectives To present the various adverse effects of topical prostaglandin analogs on the periorbita. Background The authors studied the prostaglandin-related adverse effects on the periorbita and compared each analog in a sample of patients with glaucoma. Patients and methods A case series study was performed on the adverse effects on the periorbita noticed in glaucomatous patients who were controlled by prostaglandin in Menoufia University Hospital and Cairo Fatemic Hospital. The study was done on 100 patients aged from 18 to 75 years at outpatient clinics. Results A total of 100 patients were found to have a variety of disorders, including deepening of the superior sulci (42/100), hypertrichosis (23/100), lengthening of eyelashes (48/100), and hyperpigmentation of the skin surrounding the eye (40/100). Conclusion Although topical prostaglandin analogs are well tolerated by many patients, some individuals who use these medications complain of structural changes in the periorbita, resulting in a variety of cosmetic and eyelid disorders, such as lengthening of eyelashes, hypertrichosis, hyperpigmentation of the skin surrounding the eye, and deepening of sulci.