mRNA的稳定性及基因表达的调控。

S. Liebhaber
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引用次数: 48

摘要

mRNA的稳定性在基因表达的决定中起着重要作用。mRNA的稳定性反映了它的初级和高阶结构,以及它与各种反式作用rna结合蛋白的相互作用。这两个参数都可以控制mRNA的功能及其对限速核酸酶消化的暴露。mRNA稳定性的具体决定因素现在正在明确定义的模型系统中研究出来。红系分化的转录后阶段延长所必需的珠蛋白mrna的不寻常的稳定性,提供了一个潜在的信息稳定性控制的例子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
mRNA stability and the control of gene expression.
The stability of an mRNA plays a major role in the determination of gene expression. The stability of an mRNA reflects its primary and higher-order structure, as well as its interactions with a variety of trans-acting RNA-binding proteins. Both of these parameters can control the function of the mRNA and its exposure to rate limiting nuclease digestion. The specific determinants of mRNA stability are now being worked out in well defined model systems. The unusual stability of globin mRNAs, necessitated by the prolonged posttranscriptional phase of erythroid differentiation, presents a potentially informative example of stability control.
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