mRNA的稳定性及基因表达的调控。

S. Liebhaber
{"title":"mRNA的稳定性及基因表达的调控。","authors":"S. Liebhaber","doi":"10.1002/9780470015902.A0005972.PUB2","DOIUrl":null,"url":null,"abstract":"The stability of an mRNA plays a major role in the determination of gene expression. The stability of an mRNA reflects its primary and higher-order structure, as well as its interactions with a variety of trans-acting RNA-binding proteins. Both of these parameters can control the function of the mRNA and its exposure to rate limiting nuclease digestion. The specific determinants of mRNA stability are now being worked out in well defined model systems. The unusual stability of globin mRNAs, necessitated by the prolonged posttranscriptional phase of erythroid differentiation, presents a potentially informative example of stability control.","PeriodicalId":19394,"journal":{"name":"Nucleic acids symposium series","volume":"32 1","pages":"29-32"},"PeriodicalIF":0.0000,"publicationDate":"2007-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"48","resultStr":"{\"title\":\"mRNA stability and the control of gene expression.\",\"authors\":\"S. Liebhaber\",\"doi\":\"10.1002/9780470015902.A0005972.PUB2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The stability of an mRNA plays a major role in the determination of gene expression. The stability of an mRNA reflects its primary and higher-order structure, as well as its interactions with a variety of trans-acting RNA-binding proteins. Both of these parameters can control the function of the mRNA and its exposure to rate limiting nuclease digestion. The specific determinants of mRNA stability are now being worked out in well defined model systems. The unusual stability of globin mRNAs, necessitated by the prolonged posttranscriptional phase of erythroid differentiation, presents a potentially informative example of stability control.\",\"PeriodicalId\":19394,\"journal\":{\"name\":\"Nucleic acids symposium series\",\"volume\":\"32 1\",\"pages\":\"29-32\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2007-09-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"48\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nucleic acids symposium series\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/9780470015902.A0005972.PUB2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nucleic acids symposium series","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/9780470015902.A0005972.PUB2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 48

摘要

mRNA的稳定性在基因表达的决定中起着重要作用。mRNA的稳定性反映了它的初级和高阶结构,以及它与各种反式作用rna结合蛋白的相互作用。这两个参数都可以控制mRNA的功能及其对限速核酸酶消化的暴露。mRNA稳定性的具体决定因素现在正在明确定义的模型系统中研究出来。红系分化的转录后阶段延长所必需的珠蛋白mrna的不寻常的稳定性,提供了一个潜在的信息稳定性控制的例子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
mRNA stability and the control of gene expression.
The stability of an mRNA plays a major role in the determination of gene expression. The stability of an mRNA reflects its primary and higher-order structure, as well as its interactions with a variety of trans-acting RNA-binding proteins. Both of these parameters can control the function of the mRNA and its exposure to rate limiting nuclease digestion. The specific determinants of mRNA stability are now being worked out in well defined model systems. The unusual stability of globin mRNAs, necessitated by the prolonged posttranscriptional phase of erythroid differentiation, presents a potentially informative example of stability control.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信