慢性丙型肝炎与1型自身免疫性肝炎交叉综合征转化为2型自身免疫性肝炎1例临床研究

A. O. Buyeverov, K.M. Roschina, O. Kuzmina, P. Bogomolov
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引用次数: 0

摘要

我们提出的临床病例患者最初诊断慢性丙型肝炎与自身免疫成分对应的1型自身免疫性肝炎。考虑到在诊断时丙型肝炎的治疗可能性仅限于使用标准或聚乙二醇化干扰素α联合利巴韦林,为了避免干扰素的不良免疫调节作用,我们之前使用免疫抑制剂抑制自身免疫成分。在泼尼松龙和硫唑嘌呤治疗6个月后,进行干扰素α和利巴韦林抗病毒治疗,获得持续的病毒学和生化反应。病毒学、免疫学和生化完全缓解7年后,患者表现为自身免疫性肝炎2型。强的松龙和硫唑嘌呤的使用导致了稳定的药物诱导缓解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cross-syndrome of Chronic Hepatitis C and Type 1 Autoimmune Hepatitis with Subsequent Transformation into Type 2 Autoimmune Hepatitis: a Clinical Case
We present clinical case of patient with initially diagnosed chronic hepatitis C with an autoimmune component corresponding to type 1 autoimmune hepatitis. Considering that at the time of diagnosis, the therapeutic possibilities of hepatitis C were limited to the use of standard or pegylated interferon α in combination with ribavirin, in order to avoid the adverse immunomodulatory effect of interferon, we previously suppressed the autoimmune component with immunosuppressors. After 6-month course of prednisolone and azathioprine, antiviral therapy with interferon α and ribavirin was carried out with the achievement of sustained virological and biochemical response. After 7 years of complete virological, immunological and biochemical remission, the patient manifested autoimmune hepatitis type 2. The appointment of prednisolone and azathioprine led to a stable drug-induced remission.
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