{"title":"不同种类胺的比较急性毒性和原发刺激性","authors":"R. Myers, B. Ballantyne","doi":"10.1080/107691897229702","DOIUrl":null,"url":null,"abstract":"Results of acute toxicity and prim ary irritation studies for 43 amines of 9 chem ical classes are presented. Effects were variable, even within the same structural class, but several trends were apparent. Based on LD50 values, saturated short- and long-chain aliphatic amines were of moderate to high toxicity by peroral (rat) and percutaneous (rabbit) routes. Oral LD50 values ranged from 8.0 m l/kg), and most cyclic amines (peroral LD50 2.24-5.66 ml/kg, percutaneous LD50 0.79-16.0 ml/kg). However, one cyclic amine, quinuclidine, was highly toxic by peroral and epicutaneous dosing (respective...","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1997-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"COMPARATIVE ACUTE TOXICITY AND PRIMARY IRRITANCY OF VARIOUS CLASSES OF AMINES\",\"authors\":\"R. Myers, B. Ballantyne\",\"doi\":\"10.1080/107691897229702\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Results of acute toxicity and prim ary irritation studies for 43 amines of 9 chem ical classes are presented. Effects were variable, even within the same structural class, but several trends were apparent. Based on LD50 values, saturated short- and long-chain aliphatic amines were of moderate to high toxicity by peroral (rat) and percutaneous (rabbit) routes. Oral LD50 values ranged from 8.0 m l/kg), and most cyclic amines (peroral LD50 2.24-5.66 ml/kg, percutaneous LD50 0.79-16.0 ml/kg). However, one cyclic amine, quinuclidine, was highly toxic by peroral and epicutaneous dosing (respective...\",\"PeriodicalId\":87425,\"journal\":{\"name\":\"Toxic substance mechanisms\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1997-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxic substance mechanisms\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/107691897229702\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxic substance mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/107691897229702","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
COMPARATIVE ACUTE TOXICITY AND PRIMARY IRRITANCY OF VARIOUS CLASSES OF AMINES
Results of acute toxicity and prim ary irritation studies for 43 amines of 9 chem ical classes are presented. Effects were variable, even within the same structural class, but several trends were apparent. Based on LD50 values, saturated short- and long-chain aliphatic amines were of moderate to high toxicity by peroral (rat) and percutaneous (rabbit) routes. Oral LD50 values ranged from 8.0 m l/kg), and most cyclic amines (peroral LD50 2.24-5.66 ml/kg, percutaneous LD50 0.79-16.0 ml/kg). However, one cyclic amine, quinuclidine, was highly toxic by peroral and epicutaneous dosing (respective...
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