阿霉素载药金杂化超分子水凝胶的构建

IF 2.1 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Supramolecular Chemistry Pub Date : 2021-05-04 DOI:10.1080/10610278.2021.1973002

Yong Wang, Weixia Qing

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引用次数: 0

摘要

目前，迫切需要低毒高效的药物传递系统来抑制癌细胞。本文制备了一种无毒且具有生物相容性的药物载体(mpeg -木犀草素- aunps)，并通过SEM、FT-IR、XRD、平均粒径、zeta电位和UV-Vis光谱对其进行了表征。考虑到超分子水凝胶具有多孔性，有利于药物的储存，本文报道了一种由mpeg -木犀草素- aunps和α-环糊精(α-CD)组成的稳定的超分子水凝胶自组装体。然后，超分子水凝胶负载盐酸阿霉素(DOX)并持续释放。同时，体外实验清楚地表明，水凝胶DOX (mpeg -木黄素- aunps /DOX)具有生物活性，与游离DOX相似，但由于其释放可控，对人胶质母细胞瘤细胞(U-87 MG)具有更好的细胞毒性。我们的研究结果表明，mpeg -木犀草素- aunps /DOX可能是抗癌化疗的有希望的递送系统。图形抽象

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The construction of gold hybrid supramolecular hydrogels for doxorubicin delivery

ABSTRACT Currently, drug delivery systems with low toxicity and high efficacy are urgently needed to suppress cancer cells. Herein, a non-toxic and biocompatible drug carrier (mPEG-luteolin-AuNPs) was prepared, which was characteristic by SEM, FT-IR, XRD, average particle size, zeta potential and UV-Vis spectra, respectively. Considering that the morphology of supramolecular hydrogel was porous which was good for storage of drugs, a stable supramolecular hydrogel self-assembly formed based on mPEG-luteolin-AuNPs and α-cyclodextrin (α-CD) was reported. Then, supramolecular hydrogel loaded doxorubicin hydrochloride (DOX) and sustained DOX release. Meanwhile, in vitro experiments clearly demonstrated that DOX of hydrogel (mPEG-luteolin-AuNPs/DOX) was biologically active, similar to free DOX, but with better cytotoxicity to human glioblastoma cells (U-87 MG) because of its controllable release. Our findings indicated that mPEG-luteolin-AuNPs/DOX might be promising delivery systems for anticancer chemotherapy. GRAPHICAL ABSTRACT

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来源期刊

Supramolecular Chemistry 化学-化学综合

CiteScore

3.60

自引率

3.00%

发文量

审稿时长

2.7 months

期刊介绍： Supramolecular Chemistry welcomes manuscripts from the fields and sub-disciplines related to supramolecular chemistry and non-covalent interactions. From host-guest chemistry, self-assembly and systems chemistry, through materials chemistry and biochemical systems, we interpret supramolecular chemistry in the broadest possible sense. Interdisciplinary manuscripts are particularly encouraged. Manuscript types include: high priority communications; full papers; reviews, and; Methods papers, techniques tutorials highlighting procedures and technologies that are important to the field. We aim to publish papers in a timely fashion and as soon as a paper has been accepted and typeset it will be published in electronic form on the Latest articles section of the website. The two most important review criteria are that the paper presents high-quality work that fits generally into the broad spectrum of activities in the supramolecular chemistry field. Under normal circumstances, Supramolecular Chemistry does not consider manuscripts that would be more suitable in a highly specialized journal. This includes, but is not limited to, those based mostly or exclusively on topics such as solid state/X-ray structures, computational chemistry, or electrochemistry. . The two most important review criteria are that the paper presents high-quality work that fits generally into the broad spectrum of activities in the supramolecular chemistry field.