小紫薇醇提物的抗糖尿病作用评价。链脲佐菌素诱导的糖尿病Wistar白化大鼠模型

C. Tyagi
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引用次数: 0

摘要

目的:研究小紫薇醇提物的抗糖尿病活性。(MELPR)在链脲佐菌素(STZ)诱导的糖尿病大鼠中的表达。材料与方法:采用不同浓度MELPR(200、300 mg/kg b.w.)口服,评估生化指标(血清谷氨酸丙酮酸转氨酶[SGPT]、碱性磷酸酶[ALP])、皮肤和行为活性、口服糖耐量试验、极低密度脂蛋白(VLDL)和低密度脂蛋白(LDL)、VLDL胆固醇和LDL胆固醇(VLDL- c和LDL- c)、降糖潜能。结果与讨论:抗糖尿病活性数据表明生理生化方面发生了实质性改变。小紫薇(Lagerstroemia parviflora);(MELPR),剂量为100和200 mg/kg时,胆固醇水平分别为138.0 mg/dl和125.0 mg/dl,而标准药物格列本脲在剂量为500 mg/kg时,胆固醇水平为110.0 mg/dl。研究结果表明,体重为200和300 mg/kg的stz诱导的糖尿病大鼠治疗后,总胆固醇、甘油三酯和低密度脂蛋白胆固醇水平显著降低,导致胆固醇水平显著升高。结论:在急性毒性研究中,MELPR给药至3000mg /kg时未出现毒性症状。MELPR具有降糖活性,随浓度变化。在中性和碱性培养基中,降糖活性明显高于酸性培养基。本研究证实了紫薇的降糖潜力,为开发降糖药物提供了科学验证和依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antidiabetic evaluation of methanolic extract of Lagerstroemia parviflora Roxb. in streptozotocin-induced diabetic Wistar albino rat model
Objective: The objective of research paper was to evaluate the antidiabetic activity of methanolic extract of Lagerstroemia parviflora Roxb. (MELPR) in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: The MELPR of different concentrations (200 and 300 mg/kg b.w.) was administered orally and evaluated for the estimation of biochemical parameters (serum glutamate pyruvate transaminase [SGPT], alkaline phosphatase [ALP]), skin and behavioral activity, oral glucose tolerance test and very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), VLDL cholesterol and LDL cholesterol (VLDL-C and LDL-C), and antidiabetic potential. Results and Discussion: The antidiabetic activities data indicate substantially altered physiological and biochemical aspects. In Lagerstroemia parviflora Roxb. (MELPR), the dose of 100 and 200 mg/kg shown the cholesterol level 138.0 mg/dl and 125.0 mg/dl as compared to standard drug glibenclamide which shown the cholesterol level 110.0 mg/dl at a dose of 500 mg/kg. Study result indicates that significant decrease in total cholesterol, triglyceride, and LDL cholesterol levels was observed after treating the STZ-induced diabetic rats with 200 and 300 mg/kg body weight leading to a significant increase in the cholesterol levels.Conclusion: In acute toxicity study, no toxic symptoms were observed for MELPR, up to dose 3000 mg/kg. The MELPR possesses hypoglycemic activity, which varies with concentration. In neutral and basic media, the hypoglycemic activity was considerably more than that in acidic media. This study demonstrates the antidiabetic potential of Lagerstroemia microcarpa Wight and offers scientific validation and basis to develop antidiabetic drug.
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