Effect of Short-Term Oral Vitamin D3 Supplementation on Tear Film in Dry Eye Subjects

Vitamin D deficiency is common worldwide, particularly in the Middle East and North Africa. The prevalence of vitamin D deficiency ( 0.05). No significant differences in TF grades and PRT and TBUT scores were observed between pre- and post-vitamin D3 supplementation in healthy controls. For the study group, there were strong correlations between measurements of PRT (OD) and PRT (OS) and between TBUT (OD) and TBUT (OS) pre- and post-vitamin D3 supplementation. No correlation was found between TF (OD) and TF (OS) grades pre- and post-vitamin D3 supplementation. The TF test suggests that short-term oral vitamin D3 supplementation can improve the quality of tears in dry eye subjects. Oral vitamin D3 supplementation can be potentially used as an effective treatment for subjects with dry eye symptoms. Our study offers important insights into how vitamin D3 supplementation can improve tear film in dry eye patients and in turn improving patients’ quality of life. Future studies are needed to investigate the long-term effect of vitamin D3 supplementation on the stability of the tear film.