{"title":"维生素 K 依赖性凝血因子暂时耗竭导致 COVID-19 相关颅内出血的潜在机制：一个说明性病例。","authors":"Narihide Shinoda, Shogo Tamura, Masafumi Mori, Mitsugu Nakamura, Kazuyoshi Korosue, Shigeru Kose","doi":"10.2176/jns-nmc.2021-0295","DOIUrl":null,"url":null,"abstract":"<p><p>Coronavirus disease 2019 (COVID-19)-related intracranial hemorrhage (ICH) is believed to be associated with at least one known risk factor for ICH, such as hypertension, hyperlipidemia, diabetes mellitus, severe pneumonia, or anticoagulation therapy. However, in this study, we report a case of ICH in a 14-year-old boy with mild COVID-19 infection without pneumonia who had no such risk factors. The only abnormal laboratory finding was temporary depletion of vitamin K-dependent coagulation factors. This case indicates that COVID-19 infection may cause simultaneous asymptomatic intracranial microhemorrhages and temporary depletion of vitamin K-dependent coagulation factors. This temporary depletion might transform the intracranial microhemorrhages into symptomatic ICH.</p>","PeriodicalId":38848,"journal":{"name":"Bulletin of Science, Technology and Society","volume":"7 1","pages":"63-67"},"PeriodicalIF":0.0000,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020866/pdf/","citationCount":"0","resultStr":"{\"title\":\"Potential Mechanisms of COVID-19-related Intracranial Hemorrhage Due to Temporary Depletion of Vitamin K-dependent Coagulation Factors: An Illustrative Case.\",\"authors\":\"Narihide Shinoda, Shogo Tamura, Masafumi Mori, Mitsugu Nakamura, Kazuyoshi Korosue, Shigeru Kose\",\"doi\":\"10.2176/jns-nmc.2021-0295\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Coronavirus disease 2019 (COVID-19)-related intracranial hemorrhage (ICH) is believed to be associated with at least one known risk factor for ICH, such as hypertension, hyperlipidemia, diabetes mellitus, severe pneumonia, or anticoagulation therapy. However, in this study, we report a case of ICH in a 14-year-old boy with mild COVID-19 infection without pneumonia who had no such risk factors. The only abnormal laboratory finding was temporary depletion of vitamin K-dependent coagulation factors. This case indicates that COVID-19 infection may cause simultaneous asymptomatic intracranial microhemorrhages and temporary depletion of vitamin K-dependent coagulation factors. This temporary depletion might transform the intracranial microhemorrhages into symptomatic ICH.</p>\",\"PeriodicalId\":38848,\"journal\":{\"name\":\"Bulletin of Science, Technology and Society\",\"volume\":\"7 1\",\"pages\":\"63-67\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020866/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin of Science, Technology and Society\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2176/jns-nmc.2021-0295\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"Arts and Humanities\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Science, Technology and Society","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2176/jns-nmc.2021-0295","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Arts and Humanities","Score":null,"Total":0}
引用次数: 0
摘要
与冠状病毒病 2019（COVID-19）相关的颅内出血（ICH）被认为至少与一个已知的 ICH 危险因素有关，如高血压、高脂血症、糖尿病、重症肺炎或抗凝治疗。然而，在本研究中，我们报告了一例 ICH 病例，患者是一名 14 岁男孩，患有轻度 COVID-19 感染，无肺炎，且无上述危险因素。唯一的实验室异常发现是维生素 K 依赖性凝血因子的暂时性耗竭。该病例表明，COVID-19 感染可能同时导致无症状性颅内微出血和维生素 K 依赖性凝血因子的暂时性耗竭。这种暂时性消耗可能会将颅内微出血转变为有症状的 ICH。
Potential Mechanisms of COVID-19-related Intracranial Hemorrhage Due to Temporary Depletion of Vitamin K-dependent Coagulation Factors: An Illustrative Case.
Coronavirus disease 2019 (COVID-19)-related intracranial hemorrhage (ICH) is believed to be associated with at least one known risk factor for ICH, such as hypertension, hyperlipidemia, diabetes mellitus, severe pneumonia, or anticoagulation therapy. However, in this study, we report a case of ICH in a 14-year-old boy with mild COVID-19 infection without pneumonia who had no such risk factors. The only abnormal laboratory finding was temporary depletion of vitamin K-dependent coagulation factors. This case indicates that COVID-19 infection may cause simultaneous asymptomatic intracranial microhemorrhages and temporary depletion of vitamin K-dependent coagulation factors. This temporary depletion might transform the intracranial microhemorrhages into symptomatic ICH.
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