多磷酸酯及其与抗生素复合物作用下小鼠血液生化指标的变化

M. Kozak, I. Petruh
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引用次数: 0

摘要

聚磷酸酯与抗生素的配合物是由利沃夫国立理工大学与NAAS动物生物学研究所的科学家共同开发的,以减少抗生素对动物身体的负面影响。所进行的实验可以根据肝和肾毒性的生化标记来评估抗生素、聚磷酸酯和聚磷酸酯与抗生素的复合物对实验动物身体的影响。抗生素以平均每日治疗剂量施用。结果发现,给药后小鼠的生理状态和血液生化指标均在生理正常值范围内,多磷酸酯P4及多磷酸酯P4+抗生素(阿莫西林、土霉素、多西环素)复合物。同时,肌注多磷酸酯P6及P6+抗生素复合物对小鼠有一定的负面影响,表现为标记酶:天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、碱性磷酸酶(ALP)活性的改变。我们发现AST和ALT活性增加。P6+阿莫西林和P6+土霉素复合物增加ALP活性。P4+抗生素复合物降低ALP。P6+土霉素组降低38.5%,P6+多西林组降低26.9%,P6+多西林组降低21.8%。P6+阿莫西林复合物使小鼠血肌酐浓度显著升高237%。其余试验组血肌酐浓度变化均在正常生理范围内。研究新型纳米生物聚合物转运体与抗生素配合物作用下小鼠血液生化特性,确保选择低毒抗菌药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Blood biochemical parameters in mice under the action of polyphosphate esters and their complexes with antibiotics
Complexes of polyphosphate esters with antibiotics were developed in Lviv Polytechnic National University together with scientists of Institute of Animal Biology NAAS to reduce the negative impact of antibiotics on the animal body. The conducted experiments allow assessing the effect of antibiotics, polyphosphate esters and complexes of polyphosphate esters with antibiotics on the body of laboratory animals based on biochemical markers of hepato- and nephrotoxicity. The antibiotics were administered in average daily therapeutic doses. It was found that the physiological state of mice and their blood biochemical indicators were within physiological normal values after the administration of polyphosphate ester P4 and complexes of polyphosphate ester P4+antibiotics (amoxicillin, oxytetracycline, and doxycycline). At the same time, intramuscular administration of polyphosphate ester P6 and complexes of P6+antibiotics have a certain negative effect on mice, which is manifested by changes in the activity of marker enzymes: aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP). We found an increase in AST and ALT activities. P6+amoxicillin and P6+oxytetracycline complexes increased ALP activity. Complexes P4+antibiotics decreased ALP. Blood urea content decreased after the administration of polyphosphate ester P6 by 38.5%, P6+oxytetracycline by 26.9%, P6+doxycillin by 21.8%. P6+amoxicillin complex caused a significant increase by 237% in the concentration of creatinine in the blood of mice. The changes of blood creatinine concentration of other experimental groups fell within normal physiological range. Conducted studies of blood biochemical characteristics of mice under the action of new complexes of nanobiopolymer transporters with antibiotics ensured the selection of antibacterial drugs with low toxicity.
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