{"title":"CTGF与P2/MS作为慢性肝病纤维化无创标志物的比较与评价","authors":"S. Çiftel, H. Ataseven, S. Çiftel, A. Altun","doi":"10.7197/cmj.1212431","DOIUrl":null,"url":null,"abstract":"Background/Aims: To compare CTGF (connective tissue growth factor) and P2/MS [platelet count (109 / L)] 2 / [monocyte fraction (%) x segment neutrophil fraction (%)] ratio as non-invasive tests with liver biopsy in the detection of liver fibrosis. Thus, to determine whether CTGF and P2/MS index results can be used as a noninvasive marker, in the diagnosis of chronic liver disease \nMaterials and Methods: A total of 52 chronic hepatitis patients with concurrent liver biopsy (27 female, 25 male) were included in the study group. The subjects' ages ranged between 18 and 70, and none of the subjects had undergone liver disease-related treatment. The control group was made up of a total of 31 healthy individuals without liver disease (18 female, 13 male) from similar age groups. Liver biopsy results of patients were reported at 7 stages according to Modified Knodell Scoring (ISHAK). \nResults: CTGF levels were higher in patients with chronic hepatitis (1.06±0.70 ng/ml) than the control group (0,72±0,32 ng/ml) (P","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"37 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison and Evaluation of CTGF and P2/MS as Noninvasive Markers in Fibrosis Evaluation in Chronic Liver Disease\",\"authors\":\"S. Çiftel, H. Ataseven, S. Çiftel, A. Altun\",\"doi\":\"10.7197/cmj.1212431\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background/Aims: To compare CTGF (connective tissue growth factor) and P2/MS [platelet count (109 / L)] 2 / [monocyte fraction (%) x segment neutrophil fraction (%)] ratio as non-invasive tests with liver biopsy in the detection of liver fibrosis. Thus, to determine whether CTGF and P2/MS index results can be used as a noninvasive marker, in the diagnosis of chronic liver disease \\nMaterials and Methods: A total of 52 chronic hepatitis patients with concurrent liver biopsy (27 female, 25 male) were included in the study group. The subjects' ages ranged between 18 and 70, and none of the subjects had undergone liver disease-related treatment. The control group was made up of a total of 31 healthy individuals without liver disease (18 female, 13 male) from similar age groups. Liver biopsy results of patients were reported at 7 stages according to Modified Knodell Scoring (ISHAK). \\nResults: CTGF levels were higher in patients with chronic hepatitis (1.06±0.70 ng/ml) than the control group (0,72±0,32 ng/ml) (P\",\"PeriodicalId\":10750,\"journal\":{\"name\":\"Cumhuriyet medical journal\",\"volume\":\"37 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-12-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cumhuriyet medical journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7197/cmj.1212431\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cumhuriyet medical journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7197/cmj.1212431","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Comparison and Evaluation of CTGF and P2/MS as Noninvasive Markers in Fibrosis Evaluation in Chronic Liver Disease
Background/Aims: To compare CTGF (connective tissue growth factor) and P2/MS [platelet count (109 / L)] 2 / [monocyte fraction (%) x segment neutrophil fraction (%)] ratio as non-invasive tests with liver biopsy in the detection of liver fibrosis. Thus, to determine whether CTGF and P2/MS index results can be used as a noninvasive marker, in the diagnosis of chronic liver disease
Materials and Methods: A total of 52 chronic hepatitis patients with concurrent liver biopsy (27 female, 25 male) were included in the study group. The subjects' ages ranged between 18 and 70, and none of the subjects had undergone liver disease-related treatment. The control group was made up of a total of 31 healthy individuals without liver disease (18 female, 13 male) from similar age groups. Liver biopsy results of patients were reported at 7 stages according to Modified Knodell Scoring (ISHAK).
Results: CTGF levels were higher in patients with chronic hepatitis (1.06±0.70 ng/ml) than the control group (0,72±0,32 ng/ml) (P
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