{"title":"甘脯氨酸类化合物对大鼠疼痛性攻击-防御行为中Acth-4-7作用的影响","authors":"Severyanova La, Plotnikov Dv","doi":"10.4172/2157-2526.1000160","DOIUrl":null,"url":null,"abstract":"We studied the effects of ACTH4-7 (the N-terminal fragment of the corresponding pituitary hormone molecule) on the pain-induced aggressive-defensive behavior in the foot-shock model in rats. The peptide was administered intraperitoneally in the saline at the doses 17, 50, 150 and 450 mcg/kg 12 min before the unavoidable painful stimulation of a pair of rats in an electrified camera. The analgesic and anti-aggressogenic effects of the peptide were found. These effects were significally enhanced after administration of the peptides synthesized by means of binding of the amino acids chain Pro-Gly-Pro to one or both ends of ACTH4-7 molecule. The data obtained increase the possibility of searching and using drugs to correct aggression.","PeriodicalId":15179,"journal":{"name":"Journal of Bioterrorism and Biodefense","volume":"22 1","pages":"1-3"},"PeriodicalIF":0.0000,"publicationDate":"2018-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Influence of Various Compounds with Glyprolines on Acth-4-7 Effects in Pain-Induced Aggressive-Defensive Behavior in Rats\",\"authors\":\"Severyanova La, Plotnikov Dv\",\"doi\":\"10.4172/2157-2526.1000160\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We studied the effects of ACTH4-7 (the N-terminal fragment of the corresponding pituitary hormone molecule) on the pain-induced aggressive-defensive behavior in the foot-shock model in rats. The peptide was administered intraperitoneally in the saline at the doses 17, 50, 150 and 450 mcg/kg 12 min before the unavoidable painful stimulation of a pair of rats in an electrified camera. The analgesic and anti-aggressogenic effects of the peptide were found. These effects were significally enhanced after administration of the peptides synthesized by means of binding of the amino acids chain Pro-Gly-Pro to one or both ends of ACTH4-7 molecule. The data obtained increase the possibility of searching and using drugs to correct aggression.\",\"PeriodicalId\":15179,\"journal\":{\"name\":\"Journal of Bioterrorism and Biodefense\",\"volume\":\"22 1\",\"pages\":\"1-3\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-02-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Bioterrorism and Biodefense\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4172/2157-2526.1000160\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Bioterrorism and Biodefense","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2157-2526.1000160","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Influence of Various Compounds with Glyprolines on Acth-4-7 Effects in Pain-Induced Aggressive-Defensive Behavior in Rats
We studied the effects of ACTH4-7 (the N-terminal fragment of the corresponding pituitary hormone molecule) on the pain-induced aggressive-defensive behavior in the foot-shock model in rats. The peptide was administered intraperitoneally in the saline at the doses 17, 50, 150 and 450 mcg/kg 12 min before the unavoidable painful stimulation of a pair of rats in an electrified camera. The analgesic and anti-aggressogenic effects of the peptide were found. These effects were significally enhanced after administration of the peptides synthesized by means of binding of the amino acids chain Pro-Gly-Pro to one or both ends of ACTH4-7 molecule. The data obtained increase the possibility of searching and using drugs to correct aggression.
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