壳聚糖-聚(n-乙烯基-2-吡咯烷酮)海藻酸酯布洛芬释放水凝胶的合成与表征

The Journal of Pure and Applied Chemistry Research Pub Date : 2020-10-31 DOI:10.21776/ub.jpacr.2020.009.03.558

Kartini Afriani, Trisutanti Budikania

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引用次数: 4

摘要

以Ca2+、Zn2+和甲醛为交联剂，合成了壳聚糖-聚(n-乙烯基吡咯烷酮)-海藻酸盐(Ch/PVP/Alg)水凝胶。聚合物比例为70:20:10的水凝胶具有较高的溶胀率和良好的网状结构。Ch/PVP/Alg/Ca2+溶胀率为463.73%，凝胶率为80.59%。Ch/PVP/Alg/Zn的溶胀率为489.21%，凝胶率为81.67%。Ch/PVP/Alg与甲醛交联的溶胀率为488.03%，凝胶率为85.34%。水凝胶在pH 1.2下的溶出度试验，布洛芬释放量小于30%。而在pH 7.4时，布洛芬的水凝胶释放量相对较高。Ch/PVP/Alg/Ca在30分钟内达到34.63%，Ch/PVP/Alg/Zn达到40.86%。同时，Ch/PVP/Alg/CH2O在30 min内可释放44.92%的布洛芬。采用红外(FTIR)分光光度法、差示扫描量热法(DSC)和扫描电镜(SEM)对所得水凝胶进行了表征。

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Synthesis and Characterization of Hydrogel of Chitosan-Poly (N-Vinyl-2-Pirrolidone) (PVP)- Alginate for Ibuprofen Release

Hydrogels chitosan-poly-(N-vinyl-pyrrolidone)-alginate (Ch/PVP/Alg) have been synthesized with Ca2+, Zn2+ and formaldehyde as crosslinker. Hydrogels with ratio polymer 70:20:10 give a high swelling ratio and good network. The Ch/PVP/Alg/Ca2+ has 463.73% swelling ratio and 80.59% gel. Ch/PVP/Alg/Zn has 489.21% swelling ratio and 81.67% gel. Ch/PVP/Alg crosslinked with formaldehyde result 488.03% swelling ratio and 85.34% gel. Dissolution test of hydrogels in pH 1.2 releases ibuprofen less than 30%. Whereas in the pH 7.4, the release of ibuprofen by hydrogels are relatively high. Ch/PVP/Alg/Ca reach up to 34.63% in 30 minutes and 40.86% for Ch/PVP/Alg/Zn. Meanwhile Ch/PVP/Alg/CH2O can release 44.92% of ibuprofen in 30 minutes. The obtained hydrogel was characterized using infrared (FTIR) spectrophotometry, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM).

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The Journal of Pure and Applied Chemistry Research

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