三丁基锡(IV)苯氧乙酰羟酸酯:合成、表征、生物学评价和分子对接研究

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Main Group Chemistry Pub Date : 2023-07-26 DOI:10.3233/mgc-230008

Vandna Sharma, V. Choudhary

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引用次数: 0

摘要

在预先确定的甲醇和四氢呋喃的摩尔比下，以Bu3SnCl和苯氧乙酰羟肟酸钾配体(KPAH)为原料合成了三有机锡(IV)配合物[n-Bu3Sn(C6H5OCH2CONHO)]。这些都是通过FTIR、1h NMR和质谱等光谱技术来表征的。利用循环伏安法对电化学过程进行了研究。用最小抑菌浓度(MIC)法测定其体外抗菌和抗真菌活性，发现其具有生物活性。针对真菌受体(PDB ID: 1UKC)进行配体与复合物的分子对接，研究化合物与受体之间的相互作用。

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Tri-butyltin(IV)phenoxyacetohydroxamate: Synthesis, characterization, biological evaluation and molecular docking studies

The tri-organotin(IV) complex of composition [n-Bu3Sn(C6H5OCH2CONHO)] has been synthesized by using Bu3SnCl and potassium phenoxyacetohydroxamate ligand (KPAH) in pre-determined molar ratio of methanol and tetrahydrofuran. These are characterized by spectral techniques like FTIR, 1 H NMR and mass spectrometry. Studies on electrochemical processes are carried out using cyclic voltammetry. The in vitro antibacterial and antifungal activities performed by using minimum inhibitory concentration (MIC) method has revealed complex as biologically active. Molecular docking of the ligand and complex has been performed against the fungal receptor (PDB ID: 1UKC) to study the interactions between compound and receptor.

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来源期刊

Main Group Chemistry 化学-化学综合

CiteScore

2.00

自引率

26.70%

发文量

审稿时长

>12 weeks

期刊介绍： Main Group Chemistry is intended to be a primary resource for all chemistry, engineering, biological, and materials researchers in both academia and in industry with an interest in the elements from the groups 1, 2, 12–18, lanthanides and actinides. The journal is committed to maintaining a high standard for its publications. This will be ensured by a rigorous peer-review process with most articles being reviewed by at least one editorial board member. Additionally, all manuscripts will be proofread and corrected by a dedicated copy editor located at the University of Kentucky.