开发抗COVID-19大流行候选治疗药物的策略和挑战

R. Bhatia, S. Ganti, R. Narang, R. Rawal
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引用次数: 4

摘要

尽管上述一些方法正在不断开展工作,但仍然没有药物/疫苗可用于治疗COVID-19,药物再利用提供了一种经济而快速的策略,可以在当前繁忙的情况下发现潜在的治疗剂。药物开发人员和卫生机构需要研究这一问题,并针对可能的靶点开发针对COVID-19的候选治疗药物。与药物再利用相关的挑战是单一候选治疗药物的疗效不足。与这种方法相关的另一个并发症是,需要搜索和分析大量先前报告的数据,以便有效地针对新适应症进行有效的使用同时也提供了一个很大的挑战来选择一个候选人来重新利用
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Strategies and Challenges to Develop Therapeutic Candidates against COVID-19 Pandemic
Although there is continuous work in progress in some of the above mentioned approaches, but there is still no drug/vaccine available to treat COVID-19 Drug repurposing offers an economical and rapid strategy to discover a potential therapeutic agent in the current hectic situation This compilation may be helpful to the researchers, drug developers and health agencies to look into the matter and work against the possible targets to develop a therapeutic candidate against COVID-19 The challenge associated with drug repurposing is the inadequate efficacy of single therapeutic candidate Another complication associated with this approach is to search and analyze the huge amount of previously reported data to make efficient and effective use against a new indication The complex/unclear events of the pathophysiology of SARS-CoV-2 also offer a great challenge to select a candidate for repurposing
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