帕金森病不确定性和心理应激的症状和健康结果的生物行为框架。

K. W. Austin, S. Ameringer, A. Starkweather, L. Cloud, J. Sturgill, R. Elswick
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引用次数: 8

摘要

帕金森病(PD)是一种使人衰弱的进行性神经退行性疾病,其特征是复杂的运动和非运动症状,在发病、严重程度、残疾水平和对治疗的反应性方面波动不定。PD的不可预测性和无法阻止或减缓疾病进展可能导致不确定性和心理压力。不确定性和心理压力对帕金森病的症状和健康结果有重要影响。不确定性和心理压力已被证明会使慢性疾病的症状、功能能力和生活质量恶化;然而,其因果机制尚未阐明。我们提出了一个生物行为框架来检查PD的不确定性和心理压力。该框架考虑了可能导致不确定性的因素以及可能影响PD症状和健康结果的不确定性和心理应激的神经内分泌免疫机制,最终目的是改善症状和疾病进展、功能能力和生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biobehavioral Framework of Symptom and Health Outcomes of Uncertainty and Psychological Stress in Parkinson Disease.
Parkinson disease (PD) is a debilitating, progressive neurodegenerative disorder characterized by complex motor and nonmotor symptoms that fluctuate in onset, severity, level of disability, and responsiveness to treatment. The unpredictable nature of PD and the inability to halt or slow disease progression may result in uncertainty and psychological stress. Uncertainty and psychological stress have important implications for symptom and health outcomes in PD. Uncertainty and psychological stress have been shown to worsen symptoms, functional capacity, and quality of life in chronic illnesses; however, the causal mechanisms have yet to be elucidated. We propose a biobehavioral framework for examining uncertainty and psychological stress in PD. The framework considers factors that may contribute to uncertainty and neuroendocrine-immune mechanisms of uncertainty and psychological stress that may influence symptom and health outcomes in PD, for the ultimate purpose of improving symptom and disease progression, functional capacity, and quality of life.
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