局部过氧化氢治疗脂溢性角化病的效果

I. Mohammad, Wafaa Mahmoud, Hala S A Hafiz
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引用次数: 0

摘要

脂溢性角化病(SKs)是非常常见的良性皮肤上皮性肿瘤。因此,对于这种常见疾病,迫切需要一种安全、有效、无创且美观的治疗方法。目的评价不同浓度过氧化氢(HP)外用溶液(10%和30%)治疗SK病变的效果。患者和方法50例年龄40-77岁的SK病变患者被纳入本研究,随机平均分为两组:1组25例患者每3周接受4次局部HP 10%溶液治疗,2组25例患者每3周接受4次局部HP 30%溶液治疗。通过研究评估量表、治疗前后皮肤镜检查结果及患者自我评估对病变进行临床评估。结果研究结束时,两组患者治疗前后SK病变临床分级差异均无统计学意义:1组(P=1.000)、2组(P=0.598)。治疗前后的皮肤镜图像差异无统计学意义。两组之间的改善在统计学上没有显著差异,这表明两种浓度的净结果相似。结论外用10%和30% HP溶液治疗SKs无效,无明显副作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of topical hydrogen peroxide in treatment of seborrheic keratosis
Background Seborrheic keratoses (SKs) are very common benign epithelial skin tumors. So, there is a significant need for a safe, effective, noninvasive, and cosmetically acceptable treatment for this common condition. Aim To evaluate the effect of different concentrations of hydrogen peroxide (HP)-based topical solution (10 and 30%) for the treatment of SK lesions. Patients and methods Fifty patients aged 40–77 years, with SK lesions, were enrolled in this study and were divided randomly and equally into two groups: group 1 included 25 patients who underwent four sessions of topical HP 10% solution at 3-week interval and group 2 included 25 patients who underwent four sessions of topical HP 30% solution at 3-week interval. The lesions were evaluated clinically by study-assessment scale, dermoscopic findings before and after treatment, and patient’s self-assessment. Results At the end of the study, there was a statistically insignificant difference in the clinical grade of SK lesions before and after treatment in both groups: group 1 (P=1.000) and group 2 (P=0.598). Also, there was a statistically insignificant difference between dermoscopic pictures before and after treatment. There was a statistically insignificant difference between the improvements in both groups denoting that both concentrations gave similar net results. Conclusion Topical 10 and 30% of HP solutions are not effective in the treatment of SKs with no significant side effects.
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