酪蛋白对碘过量小鼠体内及甲状腺碘代谢的影响

Q3 Medicine

中华地方病学杂志 Pub Date : 2011-11-20 DOI:10.3760/CMA.J.ISSN.1000-4955.2011.06.008

Ying Li, Y. Jun, Zhi-yi Zhang, Shu-Bin Zhang, Shou-Jun Liu, Xiao-hui Sux, Yong-xiang Ye, S. Ming, Xin Zhao, Yan Liu

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引用次数: 0

摘要

目的观察酪蛋白对高碘小鼠血、尿及甲状腺碘代谢的影响。方法采用2 × 3因子设计。饮用水中碘和酪蛋白含量分别为50和600 μg/L，食品中碘和酪蛋白含量分别为0(Ⅰ)、10%(Ⅱ)和20%(m)。6个月和12个月后用砷铈催化分光光度法测定血清、甲状腺和尿液中的碘含量。结果6个月内，50Ⅰ、50Ⅱ、50Ⅲ、600Ⅰ、600Ⅱ、600Ⅲ组血清碘水平分别为(85.59±8.78)、(64.59±9.06)、(72.53±11.69)、(110.04±9.37)、(81.06±9.94)、(86.63±19.59)μg/L;甲状腺碘含量分别为(0.21±0.09)、(0.29±0.08)、(0.24±0.05)、(0.50±0.10)、(0.37±0.13)、(0.42±0.12)g/kg;尿碘中位数分别为87.5、68.11、105.5、746.5、828.3、1014.2 μg/L。因子设计方差分析结果显示，碘和酪蛋白显著影响血清碘水平(F =27.95,18.52，均P <0.05)，但两者之间无交互作用(F =0.81,P <0.05);碘显著影响甲状腺碘含量(F =31.35,P <0.05)，碘的存在与酪蛋白相互作用(F =3.34,P <0.05)。12个月血清碘水平分别为(88.54±12.33)、(72.45±7.73)、(72.93±13.61)、(106.26±12.00)、(90.03±7.90)、(104.88±11.67)μg/L;甲状腺碘含量分别为(0.58±0.12)、(0.40±0.14)、(0.69±0.16)、(0.84±0.13)、(0.89±0.13)、(1.02±0.11)g/kg，尿碘中位数分别为104.8、121.5、102.7、829.1、1080.8 895.2 μg/L。因子设计方差分析结果显示，碘和酪蛋白显著影响血清和甲状腺碘含量(F =42.78、7.42和66.62、7.90，均P < 0.05)，但两者之间无交互作用(F =1.93、2.31，均P < 0.05)。结论长期摄入碘可显著提高血清、甲状腺和尿液中碘的含量，但酪蛋白可加速碘的排泄，部分降低其作用。关键词:碘;——酪蛋白;甲状腺

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Effects of casein on iodine metabolism in body and thyroid of mice under excessive iodine

Objective To observe the effects of casein on iodine metabolism in blood,urine and thyroid of mice under excessive iodine.Methods A 2 by 3 factorial design was used in the experiment.The levels of iodine and casein were 50 and 600 μg/L in drinking water and 0( Ⅰ ),10％( Ⅱ ),20％( m ) in food,respectively.After six and twelve months,iodine content in serum,thyroid gland and urine was determined by arsenic-cerium catalyzed spectrophotometry.Results In six months,the levels of serum iodine in 50 Ⅰ,50 Ⅱ,50Ⅲ,600 Ⅰ,600 Ⅱ,and 600Ⅲ groups were (85.59 ± 8.78),(64.59 ± 9.06),(72.53 ± 11.69),(110.04 ± 9.37),(81.06 ± 9.94),(86.63 ± 19.59)μg/L,respectively; the levels of iodine content in thyroid gland were (0.21 ± 0.09),(0.29 ±0.08),(0.24 ± 0.05),(0.50 ± 0.10),(0.37 ± 0.13),(0.42 ± 0.12)g/kg,respectively; the levels of urinary iodine median were 87.5,68.1,105.5,746.5,828.3,1014.2 μg/L,respectively.The variance analysis results of factorial design showed iodine and casein significantly influenced the serum iodine level(F =27.95,18.52,all P ＜0.05),however,there was no interaction between the two(F =0.81,P ＞ 0.05); iodine significantly influenced the iodine content in thyroid gland(F =31.35,P ＜ 0.05),the presence of iodine interacted with casein(F =3.34,P ＜0.05).In twelve months,the levels of serum iodine were (88.54 ± 12.33),(72.45 ± 7.73),(72.93 ± 13.61),( 106.26 ± 12.00),(90.03 ± 7.90),( 104.88 ± 11.67)μg/L,respectively; the levels of iodine content in thyroid gland were (0.58 ± 0.12),(0.40 ± 0.14),(0.69 ± 0.16),(0.84 ± 0.13),(0.89 ± 0.13),(1.02 ± 0.11 )g/kg,respectively;the levels of urinary iodine median were 104.8,121.5,102.7,829.1,1080.8,895.2 μg/L,respectively.The variance analysis results of factorial design showed iodine and casein significantly influenced the iodine content in serum and thyroid gland (F =42.78,7.42 and 66.62,7.90,all P ＜ 0.05),however,there was no interaction between the two(F =1.93,2.31,all P ＞ 0.05).Conclusions Long-term intake of iodine can significantly increase the iodine content in serum,thyroid gland and urine,but casein may accelerate iodine excretion and partly reduce the effect. Key words: Iodine; Caseins; Thyroid

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来源期刊

中华地方病学杂志我国对人类健康危害特别严重的地方性疾病：克山病、大骨节病、碘缺乏病、地方性氟中毒、地方性砷中毒、鼠疫、布鲁氏菌病、寄生虫、新冠肺炎等疾病，同时还报道多发性自然疫源性疾病。

CiteScore

1.60

自引率

0.00%

发文量

8714

期刊介绍： The Chinese Journal of Endemiology covers predominantly endemic diseases threatening health of the people in the areas affected by the diseases including Keshan disease, Kaschin-Beck Disease, iodine deficiency disorders, endemic fluorosis, endemic arsenism, plague, epidemic hemorrhagic fever, brucellosis, parasite diseases and the diseases related to local natural and socioeconomic conditions; and reports researches in the basic science, etiology, epidemiology, clinical practice, control as well as multidisciplinary studies on the diseases.