COX-2、MMP-9在泪腺上皮肿瘤中的表达及对预后的影响

中国实用眼科杂志 Pub Date : 2017-05-10 DOI:10.3760/CMA.J.ISSN.1006-4443.2017.05.008

Weiwei Liu, Ke Zhang

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引用次数: 0

摘要

目的探讨环氧化酶(cox)-2和基质金属蛋白酶(MMP)-9在泪腺上皮肿瘤中的表达及其与临床预后的关系。方法选取29例ACC、37例PA和8例正常相邻组织的泪腺标本。免疫组化法检测COX-2、MMP-9的表达，分析其临床意义。结果癌旁正常泪腺未检测到COX-2、MMP-9的表达。ACC组COX-2、MMP-9表达水平均高于PA组(P <0.05)。COX-2与MMP-9的表达呈正相关(P <0.01)。COX-2、MMP-9阳性表达与阴性表达在复发风险上差异均有统计学意义(P <0.05)。结论COX-2和MMP-9可能与患者预后密切相关。它们可以作为预测复发风险和制定治疗计划的联合标志物。关键词:多形性腺瘤;腺样囊性癌;Cyclooxygenase-2;矩阵metalloproteninase-9;预后

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Expression of COX-2 and MMP-9 in lacrimal gland epithelical tumors and significance to prognosis

Objective To investigate the expression of cyclooxygenase(cox)-2 and matrix metalloproteinase (MMP)-9 in lacrimal gland epithelical tumors and the relations between pathology and clinic prognosis. Methods The samples were selected from lacrimal glands of 29 cases of ACC, 37cases of PA and 8 cases adjacent normaltissues. Expression of COX-2 and MMP-9 were detected by immunohistochemistry and then the clinical significance was analyzed. Results No expression of COX-2 or MMP-9 were detected in adjacent normal lacrimal glands. The level of COX-2 and MMP-9 expressed in ACC group were both higher than those in PA group (P <0.05). There was positive correlation between expression of COX-2 and MMP-9 (P <0.01).Significant differences in the risk of recurrence between positive and negative expression of COX-2 and MMP-9 were both noted (P <0.05). Conclusions COX-2 and MMP-9 may be closely related to the prognosis of patients. They can be considered as joint markers to be applied to predict the recurrent risk and to develop the treatment plan. Key words: Pleomorphicadenoma; adenoid cystic carcinoma; Cyclooxygenase-2; Matrix metalloproteninase-9; Prognosis

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中国实用眼科杂志

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9101

期刊介绍： China Practical Ophthalmology was founded in May 1983. It is supervised by the National Health Commission of the People's Republic of China, sponsored by the Chinese Medical Association and China Medical University, and publicly distributed at home and abroad. It is a national-level excellent core academic journal of comprehensive ophthalmology and a series of journals of the Chinese Medical Association. China Practical Ophthalmology aims to guide and improve the theoretical level and actual clinical diagnosis and treatment ability of frontline ophthalmologists in my country. It is characterized by close integration with clinical practice, and timely publishes academic articles and scientific research results with high practical value to clinicians, so that readers can understand and use them, improve the theoretical level and diagnosis and treatment ability of ophthalmologists, help and support their innovative development, and is deeply welcomed and loved by ophthalmologists and readers.