{"title":"利用MALDI-TOF质谱分析聚乙二醇的三级基质","authors":"Jangmi Hong, Taehee Kim, Jeongkwon Kim","doi":"10.5478/MSL.2014.5.2.49","DOIUrl":null,"url":null,"abstract":"Abstract: The effectiveness of tertiary matrices composed of the combination of three common matrices (dihydrobenzoic acid(DHB), α -cyano-4-hydroxycinnamic acid (CHCA), and sinapinic acid (SA)) was compared with that of single or binary matri-ces in the analysis of polyethylene glycol (PEG) polymers ranging from 1400 to 10000 Da using matrix-assisted laser desorp-tion/ionization time-of-flight mass spectrometry (MALDI-TOF MS). A tertiary matrix of 2,5-DHB+CHCA+SA was the mosteffective in terms of S/N ratios. CHCA and CHCA+SA produced the highest S/N ratios among the single matrices and thebinary matrices, respectively. The improvement observed when using a tertiary matrix in analyses of PEG polymers by MALDI-TOF MS is believed to be due to the uniform morphology of the MALDI sample spots and synergistic effects arising from themixture of the three matrix materials.Keywords: MALDI-TOF MS, tertiary matrix, polyethylene glycols, 2,5-dihydrobenzoic acid, α -cyano-4-hydroxycinnamicacid, sinapinic acid","PeriodicalId":18238,"journal":{"name":"Mass Spectrometry Letters","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2014-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Tertiary Matrices for the Analysis of Polyethylene Glycols Using MALDI-TOF MS\",\"authors\":\"Jangmi Hong, Taehee Kim, Jeongkwon Kim\",\"doi\":\"10.5478/MSL.2014.5.2.49\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract: The effectiveness of tertiary matrices composed of the combination of three common matrices (dihydrobenzoic acid(DHB), α -cyano-4-hydroxycinnamic acid (CHCA), and sinapinic acid (SA)) was compared with that of single or binary matri-ces in the analysis of polyethylene glycol (PEG) polymers ranging from 1400 to 10000 Da using matrix-assisted laser desorp-tion/ionization time-of-flight mass spectrometry (MALDI-TOF MS). A tertiary matrix of 2,5-DHB+CHCA+SA was the mosteffective in terms of S/N ratios. CHCA and CHCA+SA produced the highest S/N ratios among the single matrices and thebinary matrices, respectively. The improvement observed when using a tertiary matrix in analyses of PEG polymers by MALDI-TOF MS is believed to be due to the uniform morphology of the MALDI sample spots and synergistic effects arising from themixture of the three matrix materials.Keywords: MALDI-TOF MS, tertiary matrix, polyethylene glycols, 2,5-dihydrobenzoic acid, α -cyano-4-hydroxycinnamicacid, sinapinic acid\",\"PeriodicalId\":18238,\"journal\":{\"name\":\"Mass Spectrometry Letters\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2014-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mass Spectrometry Letters\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5478/MSL.2014.5.2.49\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"SPECTROSCOPY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mass Spectrometry Letters","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5478/MSL.2014.5.2.49","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SPECTROSCOPY","Score":null,"Total":0}
Tertiary Matrices for the Analysis of Polyethylene Glycols Using MALDI-TOF MS
Abstract: The effectiveness of tertiary matrices composed of the combination of three common matrices (dihydrobenzoic acid(DHB), α -cyano-4-hydroxycinnamic acid (CHCA), and sinapinic acid (SA)) was compared with that of single or binary matri-ces in the analysis of polyethylene glycol (PEG) polymers ranging from 1400 to 10000 Da using matrix-assisted laser desorp-tion/ionization time-of-flight mass spectrometry (MALDI-TOF MS). A tertiary matrix of 2,5-DHB+CHCA+SA was the mosteffective in terms of S/N ratios. CHCA and CHCA+SA produced the highest S/N ratios among the single matrices and thebinary matrices, respectively. The improvement observed when using a tertiary matrix in analyses of PEG polymers by MALDI-TOF MS is believed to be due to the uniform morphology of the MALDI sample spots and synergistic effects arising from themixture of the three matrix materials.Keywords: MALDI-TOF MS, tertiary matrix, polyethylene glycols, 2,5-dihydrobenzoic acid, α -cyano-4-hydroxycinnamicacid, sinapinic acid
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