Maxillary Radicular Cyst Excision and Reconstruction with Concentrated Bone Marrow Aspirate Cells Mixed with Xenograft - Case Report with 7-Year Follow-up

This article presents the case of a patient with a large maxillary radicular cyst. After apicoectomy of involved teeth and excision of the cyst, the bone defect was reconstructed with biomaterial made of concentrated bone marrow aspirate mixed with xenograft. Complete surgical procedure has been described and presented as well as steps of aspirating the bone marrow from anterior iliac crest and subsequent processing of the aspirate. Authors also provide long term follow-up, which shows healing and remodeling of both soft and hard tissues. Results of this method are very promising although using bone marrow as a source of mesenchymal stem cells seems challenging in everyday practice. More research must be done to determine whether or not peripheral blood and PRF could be the accessible source of mesenchymal stem cells with competing clinical results.