运动补充美诺酮对大鼠骨骼的影响

Mehmet Özdemi̇r, S. Lok
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引用次数: 1

摘要

摘要:众所周知,运动员使用合成代谢类固醇来提高他们的表现,并引起许多健康问题。本研究旨在分析运动时补充美洛酮对大鼠骨骼的影响。研究对象为28只28日龄Wistar雄性大鼠,由英国塞尔克大学实验医学研究与应用中心主任提供。将大鼠分为4组:C组(对照组,n:6)、E组(运动组,n:7)、M组(烯酸美洛酮,n:7)和ME组(烯酸美洛酮+运动组,n:8)。给药组根据老鼠的活重每周给药。解剖大鼠前肢、后肢骨,干燥肱骨、股骨。测定各骨的长度、骨体厚度、骨皮质厚度和髓内直径点。结果以mean±SD表示。组间比较采用方差分析和邓肯检验。有统计学意义的阈值为p 0.05)。本研究结果表明,补充美诺酮能使大鼠股骨、肱骨早期骨骺闭合,并能阻止股骨、肱骨长度的增加。此外,研究发现,运动并不能减少美诺洛酮的这种负面影响。虽然被归类为合成代谢的违禁物质被认为可以提高一些运动员的表现,但由于这些物质对运动员的健康有负面影响,因此不建议使用。关键词:合成代谢类固醇,烯酸美诺酮,大鼠,股骨,肱骨
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effects of Methenolone Enanthate Supplement with Exercise on Rats’ Bones
Abstract It is known that anabolic steroids are used by athletes to increase their performance and cause many health problems. This study aims to analyze the effects of methenolone enanthate supplement with exercise on rats’ bones. The study was conducted with 28 28-day-old Wistar male rats obtained from the Chair of the Experimental Medicine Researc h and Application Center of Selc uk University. The rats were allocated into four groups: C (control, n:6), E (exercise, n:7), M (methenolone enanthate, n:7) and ME (methenolone enanthate+exercise, n:8). The required doses were arranged weekly depending on the rats’ live weight for the groups given methenolone enanthate. The rats’ front and back extremity bones were dissected, and the humerus and femur bones were dried. Each bone’s length, corpus thickness, cortex thickness and medullary diameter points were determined. The results were presented as mean±SD. ANOVA and Duncan's test were used for inter-group comparison of the data. The threshold for statistical significance was p 0.05). It was concluded based on the study results that methenolone enanthate supplement causes early epiphyseal closure in rats’ femur and humerus bones and stops the increase in these bones’ length. In addition, exercise was found not to reduce this negative effect of methenolone enanthate. Although the prohibited substances classified as anabolics are considered to increase performance by some athletes, these substances are not recommended for use due to their negative effects on athletes’ health. Keywords: anabolic steroids, methenolone enanthate, rats, femur, humerus
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