The Effects of Methenolone Enanthate Supplement with Exercise on Rats’ Bones

Abstract It is known that anabolic steroids are used by athletes to increase their performance and cause many health problems. This study aims to analyze the effects of methenolone enanthate supplement with exercise on rats’ bones. The study was conducted with 28 28-day-old Wistar male rats obtained from the Chair of the Experimental Medicine Researc h and Application Center of Selc uk University. The rats were allocated into four groups: C (control, n:6), E (exercise, n:7), M (methenolone enanthate, n:7) and ME (methenolone enanthate+exercise, n:8). The required doses were arranged weekly depending on the rats’ live weight for the groups given methenolone enanthate. The rats’ front and back extremity bones were dissected, and the humerus and femur bones were dried. Each bone’s length, corpus thickness, cortex thickness and medullary diameter points were determined. The results were presented as mean±SD. ANOVA and Duncan's test were used for inter-group comparison of the data. The threshold for statistical significance was p 0.05). It was concluded based on the study results that methenolone enanthate supplement causes early epiphyseal closure in rats’ femur and humerus bones and stops the increase in these bones’ length. In addition, exercise was found not to reduce this negative effect of methenolone enanthate. Although the prohibited substances classified as anabolics are considered to increase performance by some athletes, these substances are not recommended for use due to their negative effects on athletes’ health. Keywords: anabolic steroids, methenolone enanthate, rats, femur, humerus